Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
文献类型：期刊论文
| 作者 | Jin, Yingying1; Ni, Dalong2; Zhang, Jiawen1; Han, Fang1; Wang, Jing1; Gao, Lu1; Zhang, Hua1; Liu, Yanyan2; Cui, Zhaowen2; Yao, Zhenwei1 |
| 刊名 | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 34期号:3 |
| 英文摘要 | Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high-performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC-targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | MRI CONTRAST AGENTS ; ADVANCED COLORECTAL-CANCER ; IN-VIVO ; CIRCULATION TIME ; QUANTITATIVE MRI ; STAGE-II ; NANOPARTICLES ; DELIVERY ; ANTIBODY ; TUMOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000398089100003 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23685]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Fudan Univ, Huashan Hosp, Dept Radiol, 12 Middle Urumqi Rd, Shanghai 200040, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yingying,Ni, Dalong,Zhang, Jiawen,et al. Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(3). |
| APA | Jin, Yingying.,Ni, Dalong.,Zhang, Jiawen.,Han, Fang.,Wang, Jing.,...&Bu, Wenbo.(2017).Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(3). |
| MLA | Jin, Yingying,et al."Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.3(2017). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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