Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy
文献类型：期刊论文
| 作者 | Hu, Ping1,2; Wang, Rui1; Zhou, Lei1; Chen, Lei1; Wu, Qingsheng3; Han, Ming-Yong4; El-Toni, Ahmed Mohamed5; Zhao, Dongyuan1; Zhang, Fan1 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2017-03-21 |
| 卷号 | 89期号:6页码:3492-3500 |
| 英文摘要 | As a light-activated noninvasive cancer treatment paradigm, photodynamic therapy (PDT) has attracted extensive attention because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (O-1(2)) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near-infrared (NIR)-responsive upconversion nanoprobe has been designed and successfully applied for controlled PDT that can be optically activated by tumor associated disruption of labile Zn2+ (denoted as Zn2+ hereafter) homeostasis stimuli. Upon NIR irradiation, this theranostic probe can not only quantitatively detect the intracellular endogenous Zn2+ in situ but also selectively generate a great deal of cytotoxic reactive oxygen species (ROS) for efficiently killing breast cancer cells under the activation of excessive endogenous Zn2+, so as to maximally avoid adverse damage to normal cells. This study aims to propose a new tumor-specific PDT paradigm and, more importantly, provide a new avenue of thought for efficient cancer theranostics based on our designed highly sensitive upconversion nanoprobes. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SINGLET OXYGEN GENERATION ; OPTICAL-PROPERTIES ; PROSTATE-CANCER ; PHOTOSENSITIZER ; NANOPARTICLES ; ZINC ; LIGHT ; NANOCRYSTALS ; STRATEGY ; LAYER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000397478300035 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23729]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Fudan Univ, State Key Lab Mol Engn Polymers, Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China 4.Inst Mat Res & Engn, 2 Fusionopolis Way, Singapore 138634, Singapore 5.King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia |
| 推荐引用方式 GB/T 7714 | Hu, Ping,Wang, Rui,Zhou, Lei,et al. Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy[J]. ANALYTICAL CHEMISTRY,2017,89(6):3492-3500. |
| APA | Hu, Ping.,Wang, Rui.,Zhou, Lei.,Chen, Lei.,Wu, Qingsheng.,...&Zhang, Fan.(2017).Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy.ANALYTICAL CHEMISTRY,89(6),3492-3500. |
| MLA | Hu, Ping,et al."Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn2+ Detection and Selective On-Demand Photodynamic Therapy".ANALYTICAL CHEMISTRY 89.6(2017):3492-3500. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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