Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration
文献类型：期刊论文
| 作者 | Yu, Weilin1; Sun, Tuan-Wei3,4; Qi, Chao3,4; Ding, Zhenyu1; Zhao, Huakun1; Chen, Feng3,4; Chen, Daoyun1; Zhu, Ying-Jie3,4; Shi, Zhongmin1; He, Yaohua1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 9期号:4页码:3306-3317 |
| 关键词 | calcium phosphate drug delivery biomimetic scaffold bone regeneration |
| 英文摘要 | Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area. Compared with the hydroxyapatite nanorods prepared by using Na2HPO4 center dot 12H(2)O as the phosphorus source, the SrAPMs with a higher specific surface area were more effective in drug loading using vancomycin as the antiobiotics of choice and consequently having a higher antibacterial efficiency both on agar plates and in broths. Furthermore, to assess the potential application of SrAPMs in bone defect repair, a novel biomimetic bone tissue-engineering scaffold consisting of collagen (Coll) and SrAPMs was constructed using a freeze-drying fabrication process. Incorporation of the SrAPMs not only improved the mechanical properties, but also enhanced the osteogenesis of rat bone marrow mesenchymal stem cells. The in vivo experiments demonstrated that the SrAPMs/Coll scaffolds remarkably enhanced new bone formation compared with the Coll and APMs/Coll scaffolds in a rat critical-sized calvarial defect model at 8 weeks postimplantation. In summary, SrAPMs developed in this work are promising as antibiotic carriers and may encourage bone formation when combined with collagen. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | MESOPOROUS BIOACTIVE GLASS ; COMPOSITE SCAFFOLDS ; IN-VITRO ; HOLLOW MICROSPHERES ; PROTEIN ADSORPTION ; OSTEOGENIC DIFFERENTIATION ; TISSUE REGENERATION ; RELEASE ; SIZE ; PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393355900012 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23480]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, 600 Yishan Rd, Shanghai 200233, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 4.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Weilin,Sun, Tuan-Wei,Qi, Chao,et al. Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(4):3306-3317. |
| APA | Yu, Weilin.,Sun, Tuan-Wei.,Qi, Chao.,Ding, Zhenyu.,Zhao, Huakun.,...&He, Yaohua.(2017).Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration.ACS APPLIED MATERIALS & INTERFACES,9(4),3306-3317. |
| MLA | Yu, Weilin,et al."Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration".ACS APPLIED MATERIALS & INTERFACES 9.4(2017):3306-3317. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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