Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration
文献类型：期刊论文
| 作者 | Yu, Weilin1; Sun, Tuan-Wei2,3; Ding, Zhenyu1; Qi, Chao2,3; Zhao, Huakun1; Chen, Feng2,3; Shi, Zhongmin1; Zhu, Ying-Jie2,3; Chen, Daoyun1; He, Yaohua1,4 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2017 |
| 卷号 | 5期号:5页码:1039-1052 |
| 英文摘要 | The development of multifunctional biomaterials with drug delivery ability, and pro-osteogenic and proangiogenic activities has garnered increasing interest in the field of regenerative medicine. In the present study, hypoxia-mimicking copper (Cu)-doped mesoporous hydroxyapatite (HAP) microspheres (Cu-MHMs) were successfully synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. The Cu-MHMs doped with 0.2, 0.5 and 1 mol% Cu were prepared. The Cu-MHMs consisting of HAP nanorods or nanosheets exhibited a hierarchically mesoporous hollow structure and a high specific surface area. Then the Cu-MHMs were investigated as a drug nanocarrier using doxorubicin hydrochloride (DOX) as a model drug. The Cu-MHMs showed a relatively high drug-loading capacity and a pH-responsive drug release behavior. Furthermore, the Cu-MHMs were incorporated into a chitosan (CS) matrix to construct a biomimetic scaffold optimized for bone regeneration. The Cu-MHM/CS composite scaffolds maintained high degrees of porosity and showed a sustained release of Cu ions. More importantly, the Cu-MHM/CS scaffolds not only enhanced the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) but also promoted the migration and tube formation of EA.hy926 cells. When implanted in rat critical-sized calvarial defects, the Cu-MHM/CS scaffolds significantly enhanced bone regeneration accompanied by more new blood vessel formation at 8 weeks post-operation compared with the MHM/CS scaffolds. These results suggest that the hypoxia-mimicking Cu-MHM/CS scaffolds could encourage bone regeneration by enhancing osteogenesis and angiogenesis simultaneously, which bodes well for the reconstruction of vascularized tissue-engineered bone. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | BIOACTIVE GLASS SCAFFOLDS ; MESENCHYMAL STEM-CELLS ; STIMULATE ANGIOGENESIS ; HOLLOW MICROSPHERES ; PROTEIN ADSORPTION ; RAPID SYNTHESIS ; GROWTH ; REPAIR ; NANOSPHERES ; FRUCTOSE-1,6-BISPHOSPHATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395908000016 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23561]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, 600 Yishan Rd, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Weilin,Sun, Tuan-Wei,Ding, Zhenyu,et al. Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(5):1039-1052. |
| APA | Yu, Weilin.,Sun, Tuan-Wei.,Ding, Zhenyu.,Qi, Chao.,Zhao, Huakun.,...&He, Yaohua.(2017).Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration.JOURNAL OF MATERIALS CHEMISTRY B,5(5),1039-1052. |
| MLA | Yu, Weilin,et al."Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration".JOURNAL OF MATERIALS CHEMISTRY B 5.5(2017):1039-1052. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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