Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation
文献类型：期刊论文
| 作者 | Yu, Weilin1; Sun, Tuan-Wei2,3; Qi, Chao2,3; Ding, Zhenyu1; Zhao, Huakun1; Zhao, Shichang1; Shi, Zhongmin1; Zhu, Ying-Jie2,3; Chen, Daoyun1; He, Yaohua1,4 |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 12页码:2293-2306 |
| 关键词 | drug delivery mesoporous hydroxyapatite microspheres zinc biomimicry scaffold bone regeneration |
| 英文摘要 | Biomaterials with high osteogenic activity are desirable for sufficient healing of bone defects resulting from trauma, tumor, infection, and congenital abnormalities. Synthetic materials mimicking the structure and composition of human trabecular bone are of considerable potential in bone augmentation. In the present study, a zinc (Zn)-doped mesoporous hydroxyapatite microspheres (Zn-MHMs)/collagen scaffold (Zn-MHMs/Coll) was developed through a lyophilization fabrication process and designed to mimic the trabecular bone. The Zn-MHMs were synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. Zn-MHMs that consist of hydroxyapatite nanosheets showed relatively uniform spherical morphology, mesoporous hollow structure, high specific surface area, and homogeneous Zn distribution. They were additionally investigated as a drug nanocarrier, which was efficient in drug delivery and presented a pH-responsive drug release behavior. Furthermore, they were incorporated into the collagen matrix to construct a biomimetic scaffold optimized for bone tissue regeneration. The Zn-MHMs/Coll scaffolds showed an interconnected pore structure in the range of 100-300 mu m and a sustained release of Zn ions. More importantly, the Zn-MHMs/Coll scaffolds could enhance the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Finally, the bone defect repair results of critical-sized femoral condyle defect rat model demonstrated that the Zn-MHMs/Coll scaffolds could enhance bone regeneration compared with the Coll or MHMs/Coll scaffolds. The results suggest that the biomimetic Zn-MHMs/Coll scaffolds may be of enormous potential in bone repair and regeneration. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Nanoscience & Nanotechnology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 关键词[WOS] | ORGANIC PHOSPHORUS SOURCE ; PROTEIN ADSORPTION ; DRUG-DELIVERY ; IN-VITRO ; OSTEOGENIC DIFFERENTIATION ; SONOCHEMICAL SYNTHESIS ; HOLLOW MICROSPHERES ; CREATINE-PHOSPHATE ; BIOACTIVE GLASS ; DISODIUM SALT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000397274500003 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23575]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Weilin,Sun, Tuan-Wei,Qi, Chao,et al. Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:2293-2306. |
| APA | Yu, Weilin.,Sun, Tuan-Wei.,Qi, Chao.,Ding, Zhenyu.,Zhao, Huakun.,...&He, Yaohua.(2017).Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,2293-2306. |
| MLA | Yu, Weilin,et al."Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):2293-2306. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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