Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheresderived simvastatin sustained release system for superior bone regeneration
文献类型：期刊论文
| 作者 | Yu, Wei-Lin1; Sun, Tuan-Wei2,3; Qi, Chao2,3; Zhao, Hua-Kun1; Ding, Zhen-Yu1; Zhang, Zhi-Wang1; Sun, Ben-Ben1; Shen, Ji1; Chen, Feng2,3; Zhu, Ying-Jie2,3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-03-13 |
| 卷号 | 7 |
| 英文摘要 | Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. In this study, simvastatin with both osteogenic and angiogenic activities was incorporated into the mesoporous hydroxyapatite microspheres (MHMs) synthesized through a icrowave- assisted hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as an organic phosphorous source. The effects of the simvastatin-loaded MHMs (S-MHMs) on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and angiogenesis in EA. hy926 cells were investigated. The results showed that the S-MHMs not only enhanced the expression of osteogenic markers in rBMSCs but also promoted the migration and tube formation of EA. hy926 cells. Furthermore, the S-MHMs were incorporated into collagen matrix to construct a novel S-MHMs/ collagen composite scaffold. With the aid of MHMs, the water-insoluble simvastatin was homogenously incorporated into the hydrophilic collagen matrix and presented a sustained release profile. In vivo experiments showed that the S-MHMs/ collagen scaffolds enhanced the bone regeneration and neovascularization simultaneously. These results demonstrated that the water-insoluble simvastatin could be incorporated into the MHMs and maintained its biological activities, more importantly, the S-MHMs/ collagen scaffolds fabricated in this study are of immense potential in bone defect repair by enhancing osteogenesis and angiogenesis simultaneously. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | MESENCHYMAL STEM-CELLS ; TISSUE-ENGINEERED BONE ; MARROW STROMAL CELLS ; DRUG-DELIVERY ; OSTEOBLAST DIFFERENTIATION ; PHOSPHORUS SOURCE ; HYDROTHERMAL SYNTHESIS ; MC3T3-E1 CELLS ; IN-VITRO ; SCAFFOLDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000396050000001 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23663]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, 600 Yishan Rd, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Wei-Lin,Sun, Tuan-Wei,Qi, Chao,et al. Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheresderived simvastatin sustained release system for superior bone regeneration[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Yu, Wei-Lin.,Sun, Tuan-Wei.,Qi, Chao.,Zhao, Hua-Kun.,Ding, Zhen-Yu.,...&He, Yao-Hua.(2017).Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheresderived simvastatin sustained release system for superior bone regeneration.SCIENTIFIC REPORTS,7. |
| MLA | Yu, Wei-Lin,et al."Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheresderived simvastatin sustained release system for superior bone regeneration".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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