Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
文献类型：期刊论文
| 作者 | Cao, Huiliang1; Zhang, Wenjie2; Meng, Fanhao1; Guo, Jinshu1; Wang, Donghui1; Qian, Shi1; Jiang, Xinquan2; Liu, Xuanyong1; Chu, Paul K.3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-02-15 |
| 卷号 | 9期号:6页码:5149-5157 |
| 关键词 | silver integrin differentiation osteointegration titanium stem cells |
| 英文摘要 | Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin alpha 5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin a5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | MESENCHYMAL STEM-CELLS ; OSTEOBLAST DIFFERENTIATION ; GALVANIC CORROSION ; INTEGRIN ; OSSEOINTEGRATION ; ADHESION ; BIOMATERIALS ; INFECTION ; IMPLANTS ; SURFACES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000394481800013 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23665]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Prosthodont, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China 3.City Univ Hong Kong, Dept Phys & Mat Sci, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Huiliang,Zhang, Wenjie,Meng, Fanhao,et al. Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(6):5149-5157. |
| APA | Cao, Huiliang.,Zhang, Wenjie.,Meng, Fanhao.,Guo, Jinshu.,Wang, Donghui.,...&Chu, Paul K..(2017).Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles.ACS APPLIED MATERIALS & INTERFACES,9(6),5149-5157. |
| MLA | Cao, Huiliang,et al."Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles".ACS APPLIED MATERIALS & INTERFACES 9.6(2017):5149-5157. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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