3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration
文献类型：期刊论文
| 作者 | Yang, Chen1; Wang, Xiaoya1; Ma, Bing1; Zhu, Haibo2; Huan, Zhiguang1; Ma, Nan2; Wu, Chengtie1; Chang, Jiang1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-02-22 |
| 卷号 | 9期号:7页码:5757-5767 |
| 关键词 | 3D printing tricalcium silicate cement scaffold drug loading nanotopography osteogenesis bone formation |
| 英文摘要 | Silicate bioactive materials have been widely studied for bone regeneration because of their eminent physicochemical properties and outstanding osteogenic bioactivity, and different methods have been developed to prepare porous silicate bioactive ceramics scaffolds for bone-tissue engineering applications. Among all of these methods, the 3D-printing technique is obviously the most efficient way to control the porous structure. However, 3D-printed bioceramic porous scaffolds need high-temperature sintering, which will cause volume shrinkage and reduce the controllability of the pore structure accuracy. Unlike silicate bioceramic, bioactive silicate cements such as tricalcium silicate (Ca3SiO5 and C3S) can be self-set in water to obtain high mechanical strength under mild conditions. Another advantage of using C3S to prepare 3D scaffolds is the possibility of simultaneous drug loading. Herein, we, for the first time, demonstrated successful preparation of uniform 3D-printed C3S bone cement scaffolds with controllable 3D structure at room temperature. The scaffolds were loaded with two model drugs and showed a loading location controllable drug-release profile. In addition, we developed a surface modification process to create controllable nanotopography on the surface of pore wall of the scaffolds, which showed activity to enhance rat bone-marrow stem cells (rBMSCs) attachment, spreading, and ALP activities. The in vivo experiments revealed that the 3D-printed C3S bone cement scaffolds with nanoneedle-structured surfaces significantly improved bone regeneration, as compared to pure C3S bone cement scaffolds, suggesting that 3D-printed C3S bone cement scaffolds with controllable nanotopography surface are bioactive implantable biomaterials for bone repair. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | IN-VITRO BIOACTIVITY ; OSTEOGENIC DIFFERENTIATION ; CALCIUM SILICATE ; TRICALCIUM SILICATE ; BIOCERAMIC IMPLANTS ; COMPOSITE SCAFFOLD ; STEM-CELLS ; PHOSPHATE ; HYDROXYAPATITE ; TISSUE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000394829800012 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23733]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Xuhui Dist Cent Hosp, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Chen,Wang, Xiaoya,Ma, Bing,et al. 3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(7):5757-5767. |
| APA | Yang, Chen.,Wang, Xiaoya.,Ma, Bing.,Zhu, Haibo.,Huan, Zhiguang.,...&Chang, Jiang.(2017).3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration.ACS APPLIED MATERIALS & INTERFACES,9(7),5757-5767. |
| MLA | Yang, Chen,et al."3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration".ACS APPLIED MATERIALS & INTERFACES 9.7(2017):5757-5767. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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