中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Combinatory optimization of chromosomal integrated mevalonate pathway for beta-carotene production in Escherichia coli

文献类型:期刊论文

作者Ye, Lijun1,2; Zhang, Chunzhi1; Bi, Changhao2,3; Li, Qingyan2,3; Zhang, Xueli2,3
刊名MICROBIAL CELL FACTORIES
出版日期2016-12-01
卷号15
关键词Escherichia coli Isoprenoid beta-carotene MVA pathway RBS
英文摘要Background: Plasmid expression is a popular method in studies of MVA pathway for isoprenoid production in Escherichia coli. However, heterologous gene expression with plasmid is often not stable and might burden growth of host cells, decreases cell mass and product yield. In this study, MVA pathway was divided into three modules, and two heterologous modules were integrated into the E. coli chromosome. These modules were individually modulated with regulatory parts to optimize efficiency of the pathway in terms of downstream isoprenoid production.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]ISOPENTENYL DIPHOSPHATE ; LYCOPENE PRODUCTION ; SUCCINATE PRODUCTION ; ISOPRENOID PATHWAY ; EXPRESSION ; BIOSYNTHESIS ; TERPENOIDS ; MICROORGANISMS ; ASTAXANTHIN ; LIMONENE
收录类别SCI
语种英语
WOS记录号WOS:000389006900001
源URL[http://124.16.173.210/handle/834782/2289]  
专题天津工业生物技术研究所_代谢工程与合成生物技术研究组 毕昌昊_期刊论文
作者单位1.Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China
2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China
3.Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China
推荐引用方式
GB/T 7714
Ye, Lijun,Zhang, Chunzhi,Bi, Changhao,et al. Combinatory optimization of chromosomal integrated mevalonate pathway for beta-carotene production in Escherichia coli[J]. MICROBIAL CELL FACTORIES,2016,15.
APA Ye, Lijun,Zhang, Chunzhi,Bi, Changhao,Li, Qingyan,&Zhang, Xueli.(2016).Combinatory optimization of chromosomal integrated mevalonate pathway for beta-carotene production in Escherichia coli.MICROBIAL CELL FACTORIES,15.
MLA Ye, Lijun,et al."Combinatory optimization of chromosomal integrated mevalonate pathway for beta-carotene production in Escherichia coli".MICROBIAL CELL FACTORIES 15(2016).

入库方式: OAI收割

来源:天津工业生物技术研究所

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