A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene
文献类型：期刊论文
| 作者 | Huang, Canping1; Liu, William J.1,2; Xu, Wen3; Jin, Tao4; Zhao, Yingze1; Song, Jingdong1; Shi, Yi5; Ji, Wei1; Jia, Hao1,2; Zhou, Yongming3 |
| 刊名 | PLOS PATHOGENS
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 12期号:9 |
| 英文摘要 | The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has generated enormous interest in the biodiversity, genomics and cross-species transmission potential of coronaviruses, especially those from bats, the second most speciose order of mammals. Herein, we identified a novel coronavirus, provisionally designated Rousettus bat coronavirus GCCDC1 (Ro-BatCoV GCCDC1), in the rectal swab samples of Rousettus leschenaulti bats by using pan-coronavirus RT-PCR and next-generation sequencing. Although the virus is similar to Rousettus bat coronavirus HKU9 (Ro-BatCoVHKU9) in genome characteristics, it is sufficiently distinct to be classified as a new species according to the criteria defined by the International Committee of Taxonomy of Viruses (ICTV). More striking was that Ro-BatCoV GCCDC1 contained a unique gene integrated into the 3'-end of the genome that has no homologs in any known coronavirus, but which sequence and phylogeny analyses indicated most likely originated from the p10 gene of a bat orthoreovirus. Sub-genomic mRNA and cellular-level observations demonstrated that the p10 gene is functional and induces the formation of cell syncytia. Therefore, here we report a putative heterologous inter-family recombination event between a single-stranded, positive-sense RNA virus and a double-stranded segmented RNA virus, providing insights into the fundamental mechanisms of viral evolution. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Microbiology ; Parasitology ; Virology |
| 研究领域[WOS] | Microbiology ; Parasitology ; Virology |
| 关键词[WOS] | ACUTE RESPIRATORY SYNDROME ; INFLUENZA-C VIRUS ; HEMAGGLUTININ-ESTERASE ; MURINE CORONAVIRUSES ; RNA RECOMBINATION ; PROTEIN ; GENOMES ; SARS ; ORTHOREOVIRUS ; SEQUENCES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385621900045 |
| 源URL | [http://124.16.173.210/handle/834782/2940]  |
| 专题 | 天津工业生物技术研究所_蛋白质工程与疫苗实验室 高福_期刊论文 |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China 2.Wenzhou Med Univ, Coll Lab Med & Life Sci, Wenzhou, Peoples R China 3.Yunnan Prov Ctr Dis Control & Prevent, Kunming, Yunnan, Peoples R China 4.China Natl Genebank Shenzhen, BGI Shenzhen, Shenzhen, Peoples R China 5.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 6.Ctr Dis Control & Prevent Mengla Cty, Mengla, Yunnan, Peoples R China 7.Chinese Acad Sci, Key Lab Microbial & Metab Engn, Inst Microbiol, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing, Peoples R China 9.Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing, Peoples R China 10.Univ Sydney, Sch Biol Sci, Marie Bashir Inst Infect Dis & Biosecur, Charles Perkins Ctr, Sydney, NSW, Australia |
| 推荐引用方式 GB/T 7714 | Huang, Canping,Liu, William J.,Xu, Wen,et al. A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene[J]. PLOS PATHOGENS,2016,12(9). |
| APA | Huang, Canping.,Liu, William J..,Xu, Wen.,Jin, Tao.,Zhao, Yingze.,...&Gao, George F..(2016).A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene.PLOS PATHOGENS,12(9). |
| MLA | Huang, Canping,et al."A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene".PLOS PATHOGENS 12.9(2016). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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