A natural food sweetener with anti-pancreatic cancer properties
文献类型：期刊论文
| 作者 | Liu, C.1,2; Dai, L-H2; Dou, D-Q1; Ma, L-Q1; Sun, Y-X2 |
| 刊名 | ONCOGENESIS
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 5 |
| 英文摘要 | Mogroside V is a triterpenoid isolated from the traditional Chinese medical plant Siraitia grosvenorii. Mogroside V has a high degree of sweetness and a low calorific content. Herein, we found that mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. These results were confirmed in vivo in a mouse xenograft model of pancreatic cancer. In xenograft tumors, Ki-67 and PCNA, the most commonly used markers of tumor cell proliferation, were downregulated after intravenous administration of mogroside V. Terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that mogroside V treatment promoted apoptosis of pancreatic cancer cells in the xenograft tumors. Furthermore, we found that mogroside V treatment significantly reduced the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. These results therefore demonstrate that the natural, sweet-tasting compound mogroside V can inhibit proliferation and survival of pancreatic cancer cells via targeting multiple biological targets. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | TRADITIONAL CHINESE MEDICINE ; SIRAITIA-GROSVENORI ; GLUCOSE-METABOLISM ; CELL-CYCLE ; EXPRESSION ; STAT3 ; MOGROSIDES ; THERAPY ; PROTEIN ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375278100006 |
| 源URL | [http://124.16.173.210/handle/834782/2245]  |
| 专题 | 天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文 |
| 作者单位 | 1.Beijing Agr Univ, Minist Agr, Key Lab Urban Agr North, 7 Beinong Rd, Beijing 102206, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, C.,Dai, L-H,Dou, D-Q,et al. A natural food sweetener with anti-pancreatic cancer properties[J]. ONCOGENESIS,2016,5. |
| APA | Liu, C.,Dai, L-H,Dou, D-Q,Ma, L-Q,&Sun, Y-X.(2016).A natural food sweetener with anti-pancreatic cancer properties.ONCOGENESIS,5. |
| MLA | Liu, C.,et al."A natural food sweetener with anti-pancreatic cancer properties".ONCOGENESIS 5(2016). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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