Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer
文献类型：期刊论文
| 作者 | Liu, Can1,2,3; Dai, Longhai2; Liu, Yueping1,3; Rong, Long4; Dou, Dequan1; Sun, Yuanxia2; Ma, Lanqing1,3 |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 8期号:6 |
| 关键词 | mogroside IVe monk fruit colorectal cancer throat cancer |
| 英文摘要 | Colorectal cancer and throat cancer are the world's most prevalent neoplastic diseases, and a serious threat to human health. Plant triterpene glycosides have demonstrated antitumor activity. In this study, we investigated potential anticancer effects of mogroside IVe, a triterpenoid glycoside from monk fruit, using in vitro and in vivo models of colorectal and laryngeal cancer. The effects of mogroside IVe on the proliferation of colorectal cancer HT29 cells and throat cancer Hep-2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the expression levels of p53, phosphorylated ERK1/2, and MMP-9 were analyzed by western blotting and immunohistochemistry. The results indicated that mogroside IVe inhibited, in a dose-dependent manner, the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice, which was accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2. This study revealed the suppressive activity of mogroside IVe towards colorectal and throat cancers and identified the underlying mechanisms, suggesting that mogroside IVe may be potentially used as a biologically-active phytochemical supplement for treating colorectal and throat cancers. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Nutrition & Dietetics |
| 研究领域[WOS] | Nutrition & Dietetics |
| 关键词[WOS] | CUCURBITANE-GLYCOSIDES ; MOLECULAR-MECHANISMS ; SIRAITIA-GROSVENORI ; NATURAL-PRODUCTS ; INITIAL STEPS ; METASTASIS ; EXPRESSION ; P53 ; PROTEINS ; INVASION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378783200045 |
| 源URL | [http://124.16.173.210/handle/834782/2908]  |
| 专题 | 天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文 |
| 作者单位 | 1.Beijing Agr Univ, Key Lab Urban Agr North, Minist Agr, Beijing 102206, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 3.Beijing Collaborat Innovat Ctr Ecoenvironm Improv, Beijing 102206, Peoples R China 4.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Can,Dai, Longhai,Liu, Yueping,et al. Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer[J]. NUTRIENTS,2016,8(6). |
| APA | Liu, Can.,Dai, Longhai.,Liu, Yueping.,Rong, Long.,Dou, Dequan.,...&Ma, Lanqing.(2016).Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer.NUTRIENTS,8(6). |
| MLA | Liu, Can,et al."Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer".NUTRIENTS 8.6(2016). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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