Metalloprotein design using genetic code expansion
文献类型：期刊论文
| 作者 | Hu, Cheng1; Chan, Sunney I.2; Sawyer, Elizabeth B.1; Yu, Yang3; Wang, Jiangyun1 |
| 刊名 | CHEMICAL SOCIETY REVIEWS
 |
| 出版日期 | 2014-09-21 |
| 卷号 | 43期号:18页码:6498-6510 |
| 英文摘要 | More than one third of all proteins are metalloproteins. They catalyze important reactions such as photosynthesis, nitrogen fixation and CO2 reduction. Metalloproteins such as the olfactory receptors also serve as highly elaborate sensors. Here we review recent developments in functional metalloprotein design using the genetic code expansion approach. We show that, through the site-specific incorporation of metal-chelating unnatural amino acids (UAAs), proton and electron transfer mediators, and UAAs bearing bioorthogonal reaction groups, small soluble proteins can recapitulate and expand the important functions of complex metalloproteins. Further developments along this route may result in cell factories and live-cell sensors with unprecedented efficiency and selectivity. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CYTOCHROME-C-OXIDASE ; CHELATING AMINO-ACID ; HEME-COPPER OXIDASE ; PHOTOCLICK-CHEMISTRY ; CROSS-LINK ; GALACTOSE-OXIDASE ; ELECTRON-TRANSFER ; MAMMALIAN-CELLS ; LIVING CELLS ; PROTEINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340780400002 |
| 源URL | [http://124.16.173.210/handle/834782/2269]  |
| 专题 | 天津工业生物技术研究所_化学生物学研究 陆艺_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Cheng,Chan, Sunney I.,Sawyer, Elizabeth B.,et al. Metalloprotein design using genetic code expansion[J]. CHEMICAL SOCIETY REVIEWS,2014,43(18):6498-6510. |
| APA | Hu, Cheng,Chan, Sunney I.,Sawyer, Elizabeth B.,Yu, Yang,&Wang, Jiangyun.(2014).Metalloprotein design using genetic code expansion.CHEMICAL SOCIETY REVIEWS,43(18),6498-6510. |
| MLA | Hu, Cheng,et al."Metalloprotein design using genetic code expansion".CHEMICAL SOCIETY REVIEWS 43.18(2014):6498-6510. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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