CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population
文献类型：期刊论文
| 作者 | Li, Yongning1,2; Song, Dongjing3; Jiang, Yongshuai4; Wang, Jingwei3; Feng, Rennan5; Zhang, Liangcai6; Wang, Guangyu7; Chen, Zugen8; Wang, Renzhi1,2; Jiang, Qinghua9 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 53期号:6页码:4054-4059 |
| 关键词 | Genome-wide association studies Alzheimer's disease Polymorphism |
| 英文摘要 | Recent genome-wide association studies (GWAS) reported CR1 rs3818361 polymorphism to be an Alzheimer's disease (AD) susceptibility variant in European ancestry. Three independent studies investigated this association in Chinese population. However, these studies reported weak or no significant association. Here, we reinvestigated the association using all the samples from three independent studies in Chinese population (N = 4047, 1244 AD cases and 2803 controls). We also selected three independent studies in European ancestry population (N = 11787, 3939 AD cases and 7848 controls) to evaluate the effect of rs3818361 polymorphism on AD risk in different ethnic backgrounds. In Chinese population, we did not identified significant heterogeneity using additive, recessive, and dominant genetic models. Meta-analysis showed significant association between rs3818361 and AD with P = 6.00E-03 and P = 5.00E-03. We further identified no heterogeneity of rs3818361 polymorphism between Chinese and European populations. We found that rs3818361 polymorphism contributed to AD with similar genetic risk in Chinese and European populations. In summary, this is the first study to show significant association between rs3818361 polymorphism and AD in Chinese population by a meta-analysis method. Our findings indicate that the effect of CR1 rs3818361 polymorphism on AD risk in Chinese cohorts is consistent with the increased risk observed in European AD cohorts. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; IDENTIFIES VARIANTS ; ASIAN POPULATIONS ; COMMON VARIANTS ; FUNNEL PLOTS ; METAANALYSIS ; CLU ; ABCA7 ; RISK ; BIAS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379707600048 |
| 源URL | [http://124.16.173.210/handle/834782/2915]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Beijing 100730, Peoples R China 3.Second Hosp Harbin, Dept Neurol, Harbin, Peoples R China 4.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Rice Univ, Dept Stat, Houston, TX 77251 USA 7.First Hosp Harbin, Dept Oncol, Harbin, Peoples R China 8.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA 9.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China 10.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin Airport Econ Area, Xiqi Dao 32, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongning,Song, Dongjing,Jiang, Yongshuai,et al. CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population[J]. MOLECULAR NEUROBIOLOGY,2016,53(6):4054-4059. |
| APA | Li, Yongning.,Song, Dongjing.,Jiang, Yongshuai.,Wang, Jingwei.,Feng, Rennan.,...&Liu, Guiyou.(2016).CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population.MOLECULAR NEUROBIOLOGY,53(6),4054-4059. |
| MLA | Li, Yongning,et al."CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population".MOLECULAR NEUROBIOLOGY 53.6(2016):4054-4059. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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