Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury
文献类型：期刊论文
| 作者 | Wang, Po1,2; He, Yating1; Li, Daojing1; Han, Ranran1; Liu, Guiyou3; Kong, Dexin4; Hao, Junwei1,5 |
| 刊名 | JOURNAL OF NEUROINFLAMMATION
 |
| 出版日期 | 2016-08-22 |
| 卷号 | 13 |
| 关键词 | Cerebral ischemia reperfusion injury Inflammation ZSTK474 Microglia/macrophages PI3K/AKT/mTORC1 pathway |
| 英文摘要 | Background: Microglia/macrophages play a critical role in the inflammatory and immune processes of cerebral ischemia/reperfusion injury. Since microglia/macrophages can reversibly shift their phenotype toward either a "detrimental" or a "restorative" state in the injured central nervous system (CNS), compounds mediate that shift which could inhibit inflammation and restore the ability to alleviate cerebral ischemia/reperfusion injury would have therapeutic potential. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Neurosciences |
| 研究领域[WOS] | Immunology ; Neurosciences & Neurology |
| 关键词[WOS] | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR ; ADHESIVE REMOVAL TEST ; REGULATORY T-CELLS ; MICROGLIAL ACTIVATION ; ISCHEMIC-STROKE ; BEHAVIORAL DEFICITS ; INDUCED ARTHRITIS ; FOCAL ISCHEMIA ; BRAIN-INJURY ; RECEPTOR 4 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382837000004 |
| 源URL | [http://124.16.173.210/handle/834782/2924]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin 300052, Peoples R China 2.Baotou Cent Hosp, Dept Neurol, Baotou 014000, Inner Mongolia, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300000, Peoples R China 4.Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China 5.Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Tianjin 300052, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Po,He, Yating,Li, Daojing,et al. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury[J]. JOURNAL OF NEUROINFLAMMATION,2016,13. |
| APA | Wang, Po.,He, Yating.,Li, Daojing.,Han, Ranran.,Liu, Guiyou.,...&Hao, Junwei.(2016).Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury.JOURNAL OF NEUROINFLAMMATION,13. |
| MLA | Wang, Po,et al."Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury".JOURNAL OF NEUROINFLAMMATION 13(2016). |
入库方式： OAI收割
来源：天津工业生物技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。