CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility
文献类型：期刊论文
| 作者 | Han, Peng1; Liu, Guiyou2; Lu, Xin3; Cao, Minmin4; Yan, Youling3; Zou, Jing5; Li, Xiaobo6; Wang, Guangyu7 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2016-07-26 |
| 卷号 | 7期号:30页码:47278-47286 |
| 关键词 | genome-wide association study colorectal cancer rs9929218 meta-analysis eQTL |
| 英文摘要 | Colorectal cancer (CRC) is the third most common cancer. Large-scale genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants in European ancestry including the CDH1 rs9929218. Following GWAS and candidate studies evaluated the association between the CDH1 rs9929218 polymorphism and CRC in European, Asian and American populations. However, these studies reported inconsistent associations. Evidence shows that rs9929218 may regulate different gene expressions in different human tissues. Here, we reevaluated this association using large-scale samples from 16 studies (n=131768) using a meta-analysis method. In heterogeneity test, we did not identify significant heterogeneity among these studies. Meta-analysis using fixed effect model showed significant association between rs9929218 and CRC (P=6.16E-21, odds ratio (OR) = 0.92, 95% confidence interval (CI) 0.91-0.94). In order to validate the effect of rs9929218 variant on CDH1 expression, we further performed a functional analysis using two large-scale expression datasets. We identified significant regulation relation between rs9929218 variant and the expression of CDH1, ZFP90, RP11-354M1.2 and MCOLN2 by both cis-effect and trans-effect. In summary, our analysis highlights significant association between rs9929218 polymorphism and CRC susceptibility. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Oncology ; Cell Biology |
| 研究领域[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | GENOME-WIDE ASSOCIATION ; ALZHEIMERS-DISEASE SUSCEPTIBILITY ; SCALE SAMPLES CONFIRMS ; POLYMORPHISM CONTRIBUTES ; PATHWAY ANALYSIS ; CARDIOVASCULAR-DISEASE ; EUROPEAN AMERICANS ; CHINESE POPULATION ; ASIAN POPULATIONS ; GENETIC-VARIANTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385413000037 |
| 源URL | [http://124.16.173.210/handle/834782/2943]  |
| 专题 | 天津工业生物技术研究所_基因组分析实验室 陈祖耕_期刊论文 |
| 作者单位 | 1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Colorectal Surg, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300308, Peoples R China 3.First Hosp Harbin, Dept Gastroenterol, Harbin 150001, Peoples R China 4.First Hosp Harbin, Dept Endocrinol, Harbin 150001, Peoples R China 5.First Hosp Harbin, Dept Hematol, Harbin 150001, Peoples R China 6.Harbin Med Univ, Dept Pathol, Harbin 150081, Peoples R China 7.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gastrointestinal Med Oncol, Harbin 150040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Peng,Liu, Guiyou,Lu, Xin,et al. CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility[J]. ONCOTARGET,2016,7(30):47278-47286. |
| APA | Han, Peng.,Liu, Guiyou.,Lu, Xin.,Cao, Minmin.,Yan, Youling.,...&Wang, Guangyu.(2016).CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility.ONCOTARGET,7(30),47278-47286. |
| MLA | Han, Peng,et al."CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility".ONCOTARGET 7.30(2016):47278-47286. |
入库方式： OAI收割
来源：天津工业生物技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。