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  4. 期刊论文
Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density

文献类型：期刊论文

作者Wei, Jinsong1; Li, Ming2; Gao, Feng3; Zeng, Rong1; Liu, Guiyou4; Li, Keshen5,6,7
刊名ONCOTARGET
出版日期2016-05-24
卷号7期号:21页码:31429-31439
关键词osteoporosis bone mineral density pathway analysis genome-wide association studies
英文摘要Osteoporosis is a common human complex disease. It is mainly characterized by low bone mineral density (BMD) and low-trauma osteoporotic fractures (OF). Until now, a large proportion of heritability has yet to be explained. The existing large-scale genome-wide association studies (GWAS) provide strong support for the investigation of osteoporosis mechanisms using pathway analysis. Recent findings showed that different risk pathways may be involved in BMD in different tissues. Here, we conducted multiple pathway analyses of a large-scale lumbar spine BMD GWAS dataset (2,468,080 SNPs and 31,800 samples) using two published gene-based analysis software including ProxyGeneLD and the PLINK. Using BMD genes from ProxyGeneLD, we identified 51 significant KEGG pathways with adjusted P<0.01. Using BMD genes from PLINK, we identified 38 significant KEGG pathways with adjusted P<0.01. Interestingly, 33 pathways are shared in both methods. In summary, we not only identified the known risk pathway such as Wnt signaling, in which the top GWAS variants are significantly enriched, but also highlight some new risk pathways. Interestingly, evidence from further supports the involvement of these pathways in MBD.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]CARDIOVASCULAR-DISEASE ; RHEUMATOID-ARTHRITIS ; ALZHEIMERS-DISEASE ; GENE ; OSTEOPOROSIS ; FRACTURES ; ADHESION ; SYSTEM ; LOCI ; BMD
收录类别SCI
语种英语
WOS记录号WOS:000377746600122
源URL[http://124.16.173.210/handle/834782/2907]  
专题天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室 宋江宁_期刊论文
作者单位1.Guangdong Med Univ, Affiliated Hosp, Dept Orthoped Surg, Zhanjiang, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 4, Dept Endocrinol & Metab, Harbin, Heilongjiang, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 2, Dept Trauma & Emergency Surg, Harbin, Peoples R China
4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Beijing 100864, Peoples R China
5.Guangdong Med Univ, Inst Neurol, Affiliated Hosp, Zhanjiang, Peoples R China
6.Jinan Univ, Clin Med Res Inst, Neurol & Neurosurg Div, Stroke Ctr, Guangzhou, Guangdong, Peoples R China
7.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Jinsong,Li, Ming,Gao, Feng,et al. Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density[J]. ONCOTARGET,2016,7(21):31429-31439.
APA Wei, Jinsong,Li, Ming,Gao, Feng,Zeng, Rong,Liu, Guiyou,&Li, Keshen.(2016).Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density.ONCOTARGET,7(21),31429-31439.
MLA Wei, Jinsong,et al."Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density".ONCOTARGET 7.21(2016):31429-31439.

入库方式： OAI收割

来源：天津工业生物技术研究所

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