Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase
文献类型：期刊论文
| 作者 | Wang, Yang1; Desai, Janish2; Zhang, Yonghui1; Malwal, Satish R.1; Shin, Christopher J.1; Feng, Xinxin1; Sun, Hong3; Liu, Guizhi3; Guo, Rey-Ting3; Oldfield, Eric1,2 |
| 刊名 | CHEMMEDCHEM
 |
| 出版日期 | 2016-10-19 |
| 卷号 | 11期号:20页码:2311-2319 |
| 关键词 | benzoic acids cell-wall biosynthesis drug discovery membrane proteins Staphylococcus aureus |
| 英文摘要 | We synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of Staphylococcus aureus and Bacillus subtilis. One of the most active compounds, 5-fluoro-2-(3-(octyloxy) benzamido) benzoic acid (7, ED50 similar to 0.15 mu g mL(-1)) acted synergistically with seven antibiotics known to target bacterial cell-wall biosynthesis (a fractional inhibitory concentration index (FICI) of similar to 0.35, on average) but had indifferent effects in combinations with six non-cell-wall biosynthesis inhibitors (average FICI similar to 1.45). The most active compounds were found to inhibit two enzymes involved in isoprenoid/bacterial cell-wall biosynthesis: undecaprenyl diphosphate synthase (UPPS) and undecaprenyl diphosphate phosphatase (UPPP), but not farnesyl diphosphate synthase, and there were good correlations between bacterial cell growth inhibition, UPPS inhibition, and UPPP inhibition. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387392800007 |
| 源URL | [http://124.16.173.210/handle/834782/2299]  |
| 专题 | 天津工业生物技术研究所_结构生物学与蛋白酶学实验室 郭瑞庭_期刊论文 |
| 作者单位 | 1.Univ Illinois, Dept Chem, 600 South Mathews Ave, Urbana, IL 61801 USA 2.Univ Illinois, Ctr Biophys & Quantitat Biol, 1110 West Green St, Urbana, IL 61801 USA 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Ind Enzymes Natl Engn Lab, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yang,Desai, Janish,Zhang, Yonghui,et al. Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase[J]. CHEMMEDCHEM,2016,11(20):2311-2319. |
| APA | Wang, Yang.,Desai, Janish.,Zhang, Yonghui.,Malwal, Satish R..,Shin, Christopher J..,...&Oldfield, Eric.(2016).Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.CHEMMEDCHEM,11(20),2311-2319. |
| MLA | Wang, Yang,et al."Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase".CHEMMEDCHEM 11.20(2016):2311-2319. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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