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Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production

文献类型：期刊论文

作者Tan, Zaigao1,2; Chen, Jing1,2; Zhang, Xueli1,2
刊名BIOTECHNOLOGY FOR BIOFUELS
出版日期2016-12-01
卷号9期号:11
关键词Escherichia coli Pentose phosphate pathway (PPP) Succinate Reducing equivalent Ribosome binding site library (RBSL) Multivariate modular metabolic engineering (MMME)
英文摘要Background: Succinate biosynthesis of Escherichia coli is reducing equivalent-dependent and the EMP pathway serves as the primary reducing equivalent source under anaerobic condition. Compared with EMP, pentose phosphate pathway (PPP) is reducing equivalent-conserving but suffers from low efficacy. In this study, the ribosome binding site library and modified multivariate modular metabolic engineering (MMME) approaches are employed to overcome the low efficacy of PPP and thus increase succinate production.
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
类目[WOS]Biotechnology & Applied Microbiology ; Energy & Fuels
研究领域[WOS]Biotechnology & Applied Microbiology ; Energy & Fuels
关键词[WOS]FATTY-ACIDS PRODUCTION ; METABOLIC EVOLUTION ; CORYNEBACTERIUM-GLUTAMICUM ; CONSERVING PATHWAYS ; OPTIMIZATION ; EXPRESSION ; GLUCOSE ; GENE ; OVERPRODUCTION ; STRAINS
收录类别SCI
语种英语
WOS记录号WOS:000389380100002
源URL[http://124.16.173.210/handle/834782/2286]  
专题天津工业生物技术研究所_微生物代谢工程 张学礼_期刊论文
作者单位1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, 32 XiQiDao,Tianjin Airport Econ Pk, Tianjin 300308, Peoples R China
2.Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Zaigao,Chen, Jing,Zhang, Xueli. Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production[J]. BIOTECHNOLOGY FOR BIOFUELS,2016,9(11).
APA Tan, Zaigao,Chen, Jing,&Zhang, Xueli.(2016).Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production.BIOTECHNOLOGY FOR BIOFUELS,9(11).
MLA Tan, Zaigao,et al."Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production".BIOTECHNOLOGY FOR BIOFUELS 9.11(2016).

入库方式： OAI收割

来源：天津工业生物技术研究所

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