Pro-Apoptotic Effects of the Novel Tangeretin Derivate 5-Acetyl-6,7,8,4 '-Tetramethylnortangeretin on MCF-7 Breast Cancer Cells
文献类型：期刊论文
| 作者 | Wang, Jinhan1,2,3; Duan, Yitao1,4; Zhi, Dexian1; Li, Guangqiang2,3; Wang, Liwen1; Zhang, Hongmei5,6; Gu, Lichao5,6; Ruan, Haihua1; Zhang, Kunsheng1; Liu, Qiang2,3 |
| 刊名 | CELL BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2014-11-01 |
| 卷号 | 70期号:2页码:1255-1263 |
| 关键词 | Tangeretin derivative 5-acetyl-6,7,8,4 '-tetramethylnortangeretin MCF-7 cell line Apoptosis Cytotoxicity |
| 英文摘要 | Citrus polymethoxyflavone tangeretin (5,6,7,8,4'-pentamethoxyflavone, TAN) displays multiple biological activities, but previous reports showed that TAN failed to induce MCF-7 human breast cancer cells apoptosis. Herein, we prepared 5-acetyl-6,7,8,4'-tetramethylnortangeretin (5-ATAN), and evaluated its cytotoxicity on MCF-7 cells. 5-ATAN revealed stronger cytotoxicity than that of parent TAN in the growth inhibition of MCF-7 cells. 5-ATAN induced apoptosis via both caspase-independent and -dependent pathways, in which 5-ATAN induced the translocation of apoptosis inducing factor and phosphorylation of H2AX as well as poly (ADP-ribose) polymerase cleavage, caspase-3 activation. However, 5-ATAN did not affect extrinsic markers caspase-8, BID, and FADD. Further, 5-ATAN induced the loss of mitochondrial membrane potential (Delta psi m) by regulating the Bax/Bcl-2 ratio. Loss of Delta psi m led to the mitochondrial release of cytochrome c which triggered activation of caspase-9. In conclusion, these data indicate that 5-ATAN plays pro-apoptotic cytotoxic roles in MCF-7 cells through both caspase-dependent intrinsic apoptosis and caspase-independent apoptosis pathways. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | HYDROXYLATED POLYMETHOXYFLAVONES ; CITRUS FLAVONOIDS ; CYCLE ARREST ; DEATH ; PREVENTION ; AIF ; ACTIVATION ; CASPASE-3 ; THERAPY ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343143500067 |
| 源URL | [http://124.16.173.210/handle/834782/2273]  |
| 专题 | 天津工业生物技术研究所_总体研究部_期刊论文 |
| 作者单位 | 1.Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin Key Lab Food & Biotechnol, Tianjin, Peoples R China 2.Chinese Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China 3.Peking Union Med Coll, Tianjin, Peoples R China 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 5.Hebei Union Univ, Affiliated Hosp, Dept Hematol, Tangshan, Hebei, Peoples R China 6.Hebei Union Univ, Affiliated Hosp, Translat Med Ctr, Tangshan, Hebei, Peoples R China 7.Huanggang Normal Univ, Hubei Key Lab Econ Forest Germplasm Improvement &, Huanggang, Hubei, Peoples R China 8.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08903 USA |
| 推荐引用方式 GB/T 7714 | Wang, Jinhan,Duan, Yitao,Zhi, Dexian,et al. Pro-Apoptotic Effects of the Novel Tangeretin Derivate 5-Acetyl-6,7,8,4 '-Tetramethylnortangeretin on MCF-7 Breast Cancer Cells[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,70(2):1255-1263. |
| APA | Wang, Jinhan.,Duan, Yitao.,Zhi, Dexian.,Li, Guangqiang.,Wang, Liwen.,...&Zhao, Hui.(2014).Pro-Apoptotic Effects of the Novel Tangeretin Derivate 5-Acetyl-6,7,8,4 '-Tetramethylnortangeretin on MCF-7 Breast Cancer Cells.CELL BIOCHEMISTRY AND BIOPHYSICS,70(2),1255-1263. |
| MLA | Wang, Jinhan,et al."Pro-Apoptotic Effects of the Novel Tangeretin Derivate 5-Acetyl-6,7,8,4 '-Tetramethylnortangeretin on MCF-7 Breast Cancer Cells".CELL BIOCHEMISTRY AND BIOPHYSICS 70.2(2014):1255-1263. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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