Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis
文献类型：期刊论文
| 作者 | Qin, Mingming1; Geng, Yan1; Lu, Zhen-Ming1; Xu, Hong-Yu1; Shi, Jin-Song1; Xu, Xin2; Xu, Zheng-Hong1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:3页码:227-234 |
| 关键词 | medicinal mushrooms inflammatory bowel disease ulcerative colitis anti-inflammatory inflammatory mediators Hericeum erinaceus |
| 英文摘要 | This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation. Orally administrated ethanol extract of H. erinaceus (HEEE) (250 mg/kg/d and 500 mg/kg/d body weight) could significantly (P < 0.05) improve body weight and colon length and decreased the intestinal bleeding of DSS-treated mice compared with DSS-treated mice not given HEEE. HEEE markedly reduced DSS-induced myeloperoxidase accumulation in colon tissues, attenuated histological change in the neutrophils and lymphocyte infiltration, and protected the mucosal epithelium. Mechanistically, HEEE ameliorated colitis not only by suppressing the production of inflammatory mediators including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 in colon tissues but also by adjusting the production of nitric oxide, malondialdehyde, and superoxide dismutase in serum to suppress the oxidative stress. These results suggest that HEEE can be applied as a protective agent in the treatment of IBDs. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy |
| 关键词[WOS] | INFLAMMATORY-BOWEL-DISEASE ; SULFATE-INDUCED COLITIS ; OXIDATIVE STRESS ; RECEPTORS ; CYTOKINES ; MODELS ; MOUSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377586600005 |
| 源URL | [http://124.16.173.210/handle/834782/2899]  |
| 专题 | 天津工业生物技术研究所_总体研究部_期刊论文 |
| 作者单位 | 1.Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China 2.Wuxi 2 Peoples Hosp, Wuxi 214002, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin Key Lab Ind Biol Syst & Bioproc Engn, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Mingming,Geng, Yan,Lu, Zhen-Ming,et al. Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2016,18(3):227-234. |
| APA | Qin, Mingming.,Geng, Yan.,Lu, Zhen-Ming.,Xu, Hong-Yu.,Shi, Jin-Song.,...&Xu, Zheng-Hong.(2016).Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,18(3),227-234. |
| MLA | Qin, Mingming,et al."Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 18.3(2016):227-234. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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