Nanoframes are unique for their 3D, highly open architecture. When made of noble metals, they are attractive for use as heterogeneous catalysts because of their large specific surface areas, high densities of catalytically active sites and low vulnerability toward sintering. They promise to enhance the catalytic activity and durability while reducing the material loading and cost. For nanoframes composed of Au and/or Ag, they also exhibit highly tunable plasmonic properties similar to those of nanorods. This article presents a brief account of recent progress in the design, synthesis and utilization of noble-metal nanoframes. We start with a discussion of the synthetic strategies, including those involving site-selected deposition and etching, as well as dealloying of both hollow and solid nanocrystals. We then highlight some of the applications enabled by noble-metal nanoframes. Finally, we discuss the challenges and trends with regard to future development.