Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts
文献类型：期刊论文
| 作者 | Hu, Hua-bin ; Song, Qi-shi
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:x页码:45805 |
| 关键词 | KAPPA-B PATHWAY IN-VITRO RAW264.7 MACROPHAGES STEM BARK C-13 NMR CELLS XISHUANGBANNA FLAVONOIDS ALKALOIDS ETHER |
| 中文摘要 | In this study, 44 compounds in the petroleum ether extract of Maqian (Zanthoxylum myriacanthum var. pubescens) bark, a traditional Dai herbal medicine, were identified by GC-MS. Major components included 3(2H)-benzofuranone, asarinin and (dimethoxymethyl)-3-methoxy-benzene. A total of 18 compounds were isolated from the ethyl acetate extracts of Maqian bark by column chromatography and identified by chemical and spectral analyses. Rhoifoline B, zanthoxyline dimethoxy derivative, N-nortidine, nitidine, decarine are the major alkaloids. Both the petroleum ether and ethyl acetate extracts showed significant inhibition on NO production, which imply anti-inflammatory activity, in lipopolysaccharide-induced RAW 264.7 cells without cell toxicity. Decarine is the major antiinflammatory constituent with NO IC50 values of 48.43 mu M on RAW264.7 cells. The petroleum ether extract, the ethyl acetate extract and decarine showed anti-inflammatory activities through inhibiting TNF-alpha and IL-1 beta production in lipopolysaccharide-stimulated THP-1 cells without cell toxicity too. Decarine showed anti-inflammatory activity on human colon cells by reducing IL-6 and IL-8 production in TNF-alpha+ IL-1 beta-induced Caco-2 cells. These results support the use of Maqian bark as a remedy for enteritis and colitis recorded by Dai medicine in China, and elucidate the major pharmacological compounds in Maqian bark. |
| 语种 | 英语 |
| 公开日期 | 2017-04-28 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/10341]  |
| 专题 | 西双版纳热带植物园_民族植物学研究组 中国科学院西双版纳热带植物园 |
| 推荐引用方式 GB/T 7714 | Hu, Hua-bin,Song, Qi-shi. Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts[J]. SCIENTIFIC REPORTS,2017,7(x):45805. |
| APA | Hu, Hua-bin,&Song, Qi-shi.(2017).Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts.SCIENTIFIC REPORTS,7(x),45805. |
| MLA | Hu, Hua-bin,et al."Chemical constituents and antiinflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts".SCIENTIFIC REPORTS 7.x(2017):45805. |
入库方式： OAI收割
来源：西双版纳热带植物园
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