Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy
文献类型：期刊论文
| 作者 | Liu, Yamei1,2; Ma, Kai1,2; Jiao, Tifeng1,2; Xing, Ruirui1,2; Shen, Guizhi3; Yan, Xuehai3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-02-23 |
| 卷号 | 7 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6). The hydrophobic Ce6 nanoparticles are well stabilized in a aqueous medium by the interfacially-assembled film due to the coordination polymerization of tannic acid (TA) and ferric iron (Fe(III)). The resulting Ce6@ TA-Fe(III) complex nanoparticles (referenced as Ce6@ TA-Fe(III) NPs) significantly improves the drug loading content (similar to 65%) and have an average size of 60 nm. The Ce6@TA-Fe(III) NPs are almost non-emissive as the aggregated states, but they can light up after intracellular internalization, which thus realizes low dark toxicity and excellent phototoxicity under laser irradiation. The Ce6@TA-Fe(III) NPs prolong blood circulation, promote tumor-selective accumulation of PSs, and enhanced antitumor efficacy in comparison to the free-carrier Ce6 in vivo evaluation. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DRUG-DELIVERY ; NANOPARTICLES ; PROTEIN ; MECHANISMS ; CANCER ; LOCALIZATION ; DESTRUCTION ; LIPOSOMES ; NANODRUGS ; VEHICLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000394766100001 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21957]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yamei,Ma, Kai,Jiao, Tifeng,et al. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Liu, Yamei,Ma, Kai,Jiao, Tifeng,Xing, Ruirui,Shen, Guizhi,&Yan, Xuehai.(2017).Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy.SCIENTIFIC REPORTS,7. |
| MLA | Liu, Yamei,et al."Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：过程工程研究所
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