Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy
文献类型：期刊论文
| 作者 | Dong, Qianqian1,2; Li, Jieling2; Cui, Lingyun2; Jian, Honglei2; Wang, Anhe2; Bai, Shuo2 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2017-03-05 |
| 卷号 | 516页码:190-198 |
| 关键词 | CaCO3 nanoparticles Hyaluronic acid Photosensitizer Photodynamic therapy |
| ISSN号 | 0927-7757 |
| 英文摘要 | The solubility and stability of hydrophobic photosensitizer in aqueous solution have a great effect on the efficiency of Photodynamic Therapy (PDT) in cancer treatment. Herein, porous CaCO3 nanoparticles with a size about 250 nm were prepared as a carrier for the photosensitizer Hypocrellin B (HB) to improve the encapsulation and delivery in aqueous solution. The encapsulation dosage of HB by porous CaCO3 nanoparticles was investigated and proved to be concentration dependent. After modified by cross-linked targeting molecule hyaluronic acid (HA), the hybrid nanoparticles were demonstrated the advantages for HB release by pH sensitive structure and enhancement of PDT cytotoxicity to cancer cells. The hybrid nanoparticles obtained here are supposed to have a great potential application in the PDT. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SILICA NANOPARTICLES ; SOLVENT EXCHANGE ; GOLD NANOCAGES ; DRUG-RELEASE ; CANCER-CELLS ; PARTICLES ; DELIVERY ; BIOMINERALIZATION ; CAPSULES ; BEADS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393727700021 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21962]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Harbin Univ Sci & Technol, Coll Chem & Environm Engn, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Qianqian,Li, Jieling,Cui, Lingyun,et al. Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,516:190-198. |
| APA | Dong, Qianqian,Li, Jieling,Cui, Lingyun,Jian, Honglei,Wang, Anhe,&Bai, Shuo.(2017).Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,516,190-198. |
| MLA | Dong, Qianqian,et al."Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 516(2017):190-198. |
入库方式： OAI收割
来源：过程工程研究所
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