Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments
文献类型：期刊论文
| 作者 | Jiao CX1,2,3; Zhou H1,4; Mao RR1,2; Xu L[*]1,2; Zhou QX[*]1,2; Yang CX1,2; Ma C1,2; Yang YX1,2 |
| 刊名 | Neuropsychiatric Disease and Treatment
 |
| 出版日期 | 2017 |
| 卷号 | 13期号:X页码:1181-1192 |
| 关键词 | salvianolic acid A memory impairments dementia ischemic stroke |
| 通讯作者 | lxu@vip.163.com ; qixin_zhou@126.com |
| 英文摘要 | With respect to the high burden of ischemic stroke and the absence of pharmacological treatment for promoting rehabilitation, promising candidates with specific effects on long-term functional recovery are highly desired. Candidates need reasonable experimental paradigms to evaluate the long-term functional outcome focused on ischemia-induced sensorimotor and memory deficits. "Danshen", a traditional Chinese herb, has long been used to treat coronary and cerebral vascular diseases as well as dementia. Salvianolic acid A (SAA), one of the major active ingredients of Danshen, was demonstrated to be effective in protecting against cerebral ischemic injury. Here, employing an experimental stroke model induced by photothrombosis in the unilateral frontal cortex of rats, we investigated whether SAA has long-term protective effects on ischemia-induced sensorimotor and memory deficits in our behavioral tests. The results indicated that a single SAA treatment improved the cortical ischemia-induced sensorimotor deficits during 15 days' cylinder test period, and alleviated ischemia-induced sustained spatial memory impairments during the 2 months' dependent Morris Water Maze (MWM) tests. In addition, either ischemic injury or SAA treatment did not show any changes compared with sham group in other behavioral tests including rotarod tests, swimming speed in MWM tests, open field tests, elevated plus maze tests, treadmill tests and forced swimming tests. The results reveal that the cognitive deficits are not the results of animal's anxiety or confounding motor impairments. Overall, the present paradigm appears suitable for the preclinical evaluation of the long-term effects of pharmacological treatments on ischemic stroke. Meanwhile, SAA might have therapeutic potential for the treatment of memory deficits associated with ischemic stroke. |
| 资助信息 | This work was supported by National Basic Research Program of China (2013CB835103, 2015CB553502), Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002), National Natural Science Foundation of China (81171294, U1502221, 31371141, 81360679), and Science and Technology Program of Yunnan Province (2013GA003, 2013FA048). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11485]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Key laboratory of animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming, 2.Kunming College of Life Sciences, University of chinese academy of sciences 3.Yunnan Provincial Key Laboratory of Entomollogical Biopharmaceutical research and Development, College of Pharmacy and chemistry, Dali University, Dali 4.school of life sciences, University of Science and Technology of China, hefei, People’s republic of china |
| 推荐引用方式 GB/T 7714 | Jiao CX,Zhou H,Mao RR,et al. Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments[J]. Neuropsychiatric Disease and Treatment,2017,13(X):1181-1192. |
| APA | Jiao CX.,Zhou H.,Mao RR.,Xu L[*].,Zhou QX[*].,...&Yang YX.(2017).Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments.Neuropsychiatric Disease and Treatment,13(X),1181-1192. |
| MLA | Jiao CX,et al."Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments".Neuropsychiatric Disease and Treatment 13.X(2017):1181-1192. |
入库方式： OAI收割
来源：昆明动物研究所
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