Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis
文献类型：期刊论文
| 作者 | Dai Z1,3; Li SR1,3; Liu YP2; Luo XD[*]2; Zhao XD[*]1; Zhu PF2,3; Liu L2,3; Wang B2,3 |
| 刊名 | Bioorganic & Medicinal Chemistry Letters
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:In press |
| 关键词 | Isocostunolide Glioma stem cells Cell proliferation Apoptosis Colony formation |
| 通讯作者 | xdluo@mail.kib.ac.cn ; zhaoxudong@mail.kiz.ac.cn |
| 英文摘要 | Glioblastoma multiform (GBM) is a highly aggressive brain tumor with poor life expectancy, and glioma stem cells (GSCs) are a small population of tumor cells existed in GBM, in which GSCs response to drive GBM recurrence, invasion and contribute to the anti-cancer resistance. GSCs have been identified and developed as a therapeutic target for GBM and can be used in drugs screening. Isocostunolide is a natural sesquiterpenoid and contained abundant resource in medicinal plants, but the anti-cancer efficacies of it against GSCs are still unexplored. In this investigation, the anti-tumor activity of isocostunolide against GSCs was investigated and the result demonstrated that it inhibited the growth of GSCs (GSC-3#, GSC-12#, GSC-18#) significantly with an IC50 value of 2.80μg/ml, 2.61μg/ml, 1.07μg/ml, respectively. In further mechanism study, isocostunolide inhibited GSCs cell proliferation, induced GSCs apoptosis significantly, as well as increased the proportion of the cleavage of caspase-3. The result suggested that isocostunolide induced GSCs apoptosis via the caspase dependent apoptotic pathway. Moreover, isocostunolide damaged GSCs colony formation capacity significantly and exhibited the anti-cancer efficacy against GSCs in vitro. |
| 资助信息 | This work was partly supported by the National Natural Science Foundation of China (NSFC, 81472862), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA 01040403), the Top Talents Program of Yunnan Province, China (2012HA014), and the Yunnan Applied Basic Research Projects (2013FA020). |
| 收录类别 | SCI |
| 语种 | 中文 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11486]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_肿瘤干细胞生物学 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China |
| 推荐引用方式 GB/T 7714 | Dai Z,Li SR,Liu YP,et al. Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis[J]. Bioorganic & Medicinal Chemistry Letters,2017,**(**):In press. |
| APA | Dai Z.,Li SR.,Liu YP.,Luo XD[*].,Zhao XD[*].,...&Wang B.(2017).Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis.Bioorganic & Medicinal Chemistry Letters,**(**),In press. |
| MLA | Dai Z,et al."Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis".Bioorganic & Medicinal Chemistry Letters **.**(2017):In press. |
入库方式： OAI收割
来源：昆明动物研究所
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