Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway
文献类型：期刊论文
| 作者 | Chen HM1,2,3,4; Lu CJ1,3,4,5; Yan YH1,3; Han L[*]1,3,4,5; Liu HZ1,3,4; Wang MJ1,3,4; Zhao H6,7 |
| 刊名 | International Immunopharmacology
 |
| 出版日期 | 2017 |
| 卷号 | 48期号:X页码:110-117 |
| 关键词 | Quercetin Imiquimod Psoriasis NF-κB pathway Mice |
| 通讯作者 | luchuanjian888@vip.sina.com ; linghan36@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Quercetin (QC) is a dietary flavonoid abundant in many natural plants. A series of studies have shown that it has been shown to exhibit several biological properties, including anti-inflammatory, anti-oxidant, cardio-protective, vasodilatory, liver-protective and anti-cancer activities. However, so far the possible therapeutic effect of QC on psoriasis has not been reported. The present study was undertaken to evaluate the potential beneficial effect of QC in psoriasis using a generated imiquimod (IMQ)-induced psoriasis-like mouse model, and to further elucidate its underlying mechanisms of action. Effects of QC on PASI scores, back temperature, histopathological changes, oxidative/anti-oxidative indexes, pro-inflammatory cytokines and NF-κB pathway in IMQ-induced mice were investigated. Our results showed that QC could significantly reduce the PASI scores, decrease the temperature of the psoriasis-like lesions, and ameliorate the deteriorating histopathology in IMQ-induced mice. Moreover, QC effectively attenuated levels of TNF-α, IL-6 and IL-17 in serum, increased activities of GSH, CAT and SOD, and decreased the accumulation of MDA in skin tissue induced by IMQ in mice. The mechanism may be associated with the down-regulation of NF-κB, IKKα, NIK and RelB expression and up-regulation of TRAF3, which were critically involved in the non-canonical NF-κB pathway. In conclusion, our present study demonstrated that QC had appreciable anti-psoriasis effects in IMQ-induced mice, and the underlying mechanism may involve the improvement of antioxidant and anti-inflammatory status and inhibition on the activation of the NF-κB signaling. Hence, QC, a naturally occurring flavone with potent anti-psoriatic effects, has the potential for further development as a candidate for psoriasis treatment. |
| 资助信息 | This work was supported by grants from the Chinese Medicine Scientific Research Project of Guangdong Province (No. 20161096), Chinese Medicine Scientific Research and Technology Research Projects of Chinese Medicine Hospital of Guangdong Province and the Key Discipline Construction Projects of Integrative Medicine of High Level University of Guangdong Province (No. YN2015QN05&YN2015MS20), Science and Technology Planning Project of Guangdong Province (No. 2015B020211013), Natural Science Foundation of Guangdong Province (No. S2013030011515), Traditional Chinese Medicine Clinical Research Base of China (No. JDZX2015196) and China Postdoctoral Science Foundation (2016M600649). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11483]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510115, PR Chin 2.Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China 3.Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510115, PR China 4.Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China 5.Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510115, PR China 6.Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, 999077, Hong Kong, China 7.Kunming Institute of Zoology, Chinese Academy of Sciences, Chinese University of Hong Kong, Joint Laboratory of Bioresources and Molecular Research of Common Diseases, 999077, Hong Kong, China |
| 推荐引用方式 GB/T 7714 | Chen HM,Lu CJ,Yan YH,et al. Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway[J]. International Immunopharmacology,2017,48(X):110-117. |
| APA | Chen HM.,Lu CJ.,Yan YH.,Han L[*].,Liu HZ.,...&Zhao H.(2017).Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway.International Immunopharmacology,48(X),110-117. |
| MLA | Chen HM,et al."Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway".International Immunopharmacology 48.X(2017):110-117. |
入库方式： OAI收割
来源：昆明动物研究所
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