FGF13 Selectively Regulates Heat Nociception by Interacting with Na(v)1.7
文献类型：期刊论文
| 作者 | Yang, Liu1,2; Dong, Fei1,2; Yang, Qing4; Yang, Pai-Feng; Wu, Ruiqi6,7; Wu, Qing-Feng1,2; Wu, Dan1,2; Li, Chang-Lin1,2; Zhong, Yan-Qing1,2; Lu, Ying-Jin1,2 |
| 刊名 | NEURON
 |
| 出版日期 | 2017-02-22 |
| 卷号 | 93期号:4页码:806-+ |
| 英文摘要 | The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered mechanisms. We found that the loss of an intracellular fibroblast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolished heat nociception. The noxious heat stimuli could not evoke the sustained action potential firing in FGF13-deficient DRG neurons. Furthermore, FGF13 interacted with the sodium channel Na(v)1.7 in a heat-facilitated manner. FGF13 increased Na(v)1.7 sodium currents and maintained the membrane localization of Na(v)1.7 during noxious heat stimulation, enabling the sustained firing of action potentials. Disrupting the FGF13/Na(v)1.7 interaction reduced the heat-evoked action potential firing and nociceptive behavior. Thus, beyond the thermosensors, the FGF13/Na(v)1.7 complex is essential for sustaining the transmission of noxious heat signals. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | GATED SODIUM-CHANNELS ; FIBROBLAST GROWTH-FACTORS ; DORSAL-ROOT GANGLION ; HOMOLOGOUS FACTOR 1B ; MICE LACKING ; NEURONAL EXCITABILITY ; NEURAL DEVELOPMENT ; INFLAMMATORY PAIN ; NEUROPATHIC PAIN ; SCN9A MUTATIONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000396429100012 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/10047]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, CAS Ctr Excellence Cell Biol,Inst Biochem & Cell, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, XuHui Cent Hosp, Shanghai Clin Res Ctr, Shanghai 200031, Peoples R China 5.Vanderbilt Univ, Med Ctr, Dept Radiol & Radiol Sci, Inst Imaging Sci, Nashville, TN 37232 USA 6.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 7.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 8.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 9.Shanghai Jiao Tong Univ, Discipline Neurosci, Collaborat Innovat Ctr Brain Sci, Sch Med, Shanghai 200025, Peoples R China 10.Shanghai Jiao Tong Univ, Dept Anat Histol & Embryol, Collaborat Innovat Ctr Brain Sci, Sch Med, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Liu,Dong, Fei,Yang, Qing,et al. FGF13 Selectively Regulates Heat Nociception by Interacting with Na(v)1.7[J]. NEURON,2017,93(4):806-+. |
| APA | Yang, Liu.,Dong, Fei.,Yang, Qing.,Yang, Pai-Feng.,Wu, Ruiqi.,...&Zhang, Xu.(2017).FGF13 Selectively Regulates Heat Nociception by Interacting with Na(v)1.7.NEURON,93(4),806-+. |
| MLA | Yang, Liu,et al."FGF13 Selectively Regulates Heat Nociception by Interacting with Na(v)1.7".NEURON 93.4(2017):806-+. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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