Effects of nicotine on response inhibition and interference control
文献类型:期刊论文
作者 | Ettinger, Ulrich1; Faiola, Eliana1; Kasparbauer, Anna-Maria1; Petrovsky, Nadine1; Chan, Raymond C. K.2,3; Liepelt, Roman4; Kumari, Veena5 |
刊名 | PSYCHOPHARMACOLOGY |
出版日期 | 2017-04-01 |
卷号 | 234期号:7页码:1093-1111 |
通讯作者邮箱 | ulrich.ettinger@uni-bonn.de |
ISSN号 | 0033-3158 |
关键词 | Nicotine Acetylcholine Cognition Executive function Inhibitory control Attention |
通讯作者 | Ulrich Ettinger |
英文摘要 | Nicotine is a cholinergic agonist with known procognitive effects in the domains of alerting and orienting attention. However, its effects on attentional top-down functions such as response inhibition and interference control are less well characterised. Here, we investigated the effects of 7 mg transdermal nicotine on performance on a battery of response inhibition and interference control tasks. A sample of N = 44 healthy adult non-smokers performed antisaccade, stop signal, Stroop, go/no-go, flanker, shape matching and Simon tasks, as well as the attentional network test (ANT) and a continuous performance task (CPT). Nicotine was administered in a with-in-subjects, double-blind, placebo-controlled design, with order of drug administration counterbalanced. Relative to placebo, nicotine led to significantly shorter reaction times on a prosaccade task and on CPT hits but did not significantly improve inhibitory or interference control performance on any task. Instead, nicotine had a negative influence in increasing the interference effect on the Simon task. Nicotine did not alter inter-individual associations between reaction times on congruent trials and error rates on incongruent trials on any task. Finally, there were effects involving order of drug administration, suggesting practice effects but also beneficial nicotine effects when the compound was administered first. Overall, our findings support previous studies showing positive effects of nicotine on basic attentional functions but do not provide direct evidence for an improvement of top-down cognitive control through acute administration of nicotine at this dose in healthy non-smokers. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
关键词[WOS] | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; LATENT-VARIABLE ANALYSIS ; SACCADIC EYE-MOVEMENTS ; BEHAVIORAL-INHIBITION ; COGNITIVE ENHANCEMENT ; EXECUTIVE FUNCTIONS ; NEVER-SMOKERS ; ANTISACCADE PERFORMANCE ; INDIVIDUAL-DIFFERENCES ; SUBCUTANEOUS NICOTINE |
收录类别 | SCI ; SSCI |
语种 | 英语 |
WOS记录号 | WOS:000398364200005 |
源URL | [http://ir.psych.ac.cn/handle/311026/21329] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany 2.Inst Psychol, CAS Key Lab Mental Hlth, NACN Lab, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.German Sport Univ Cologne, Inst Psychol, Cologne, Germany 5.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England |
推荐引用方式 GB/T 7714 | Ettinger, Ulrich,Faiola, Eliana,Kasparbauer, Anna-Maria,et al. Effects of nicotine on response inhibition and interference control[J]. PSYCHOPHARMACOLOGY,2017,234(7):1093-1111. |
APA | Ettinger, Ulrich.,Faiola, Eliana.,Kasparbauer, Anna-Maria.,Petrovsky, Nadine.,Chan, Raymond C. K..,...&Kumari, Veena.(2017).Effects of nicotine on response inhibition and interference control.PSYCHOPHARMACOLOGY,234(7),1093-1111. |
MLA | Ettinger, Ulrich,et al."Effects of nicotine on response inhibition and interference control".PSYCHOPHARMACOLOGY 234.7(2017):1093-1111. |
入库方式: OAI收割
来源:心理研究所
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