Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers
文献类型：期刊论文
| 作者 | Li, Fei1,2; Howard, Karyn D.1; Myers, Michael J.1 |
| 刊名 | JOURNAL OF PHARMACY AND PHARMACOLOGY
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 69期号:3页码:274-284 |
| 关键词 | ABCB1-1 Delta Collies enantiomer fexofenadine fluorescence |
| 英文摘要 | Objectives P-glycoprotein (P-gp) is responsible for the efflux of a broad variety of human and veterinary drugs. Canine P-gp polymorphisms alter drug disposition and toxicity, but their impact on the disposition of enantiomeric drugs is unknown. Using fexofenadine as a model compound, we developed and validated HPLC-fluorescence methods to determine the effect of P-gp on the disposition of fexofenadine and its enantiomers. |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | PERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; DRUG-INTERACTIONS ; HUMAN PLASMA ; QUANTITATIVE-DETERMINATION ; FLUORESCENCE DETECTION ; SHORT-TERM ; PHARMACOKINETICS ; ABCB1 ; HPLC |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395189200006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51001]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.US FDA, Div Appl Vet Res, Res Off, Ctr Vet Med, Laurel, MD USA 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Fei,Howard, Karyn D.,Myers, Michael J.. Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2017,69(3):274-284. |
| APA | Li, Fei,Howard, Karyn D.,&Myers, Michael J..(2017).Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers.JOURNAL OF PHARMACY AND PHARMACOLOGY,69(3),274-284. |
| MLA | Li, Fei,et al."Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers".JOURNAL OF PHARMACY AND PHARMACOLOGY 69.3(2017):274-284. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。