Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23
文献类型：期刊论文
| 作者 | Hu, Zhengxi1; Sun, Weiguang1; Li, Qin1; Li, Xiao-Nian1,2; Zhu, Hucheng; Huang, Jinfeng1; Liu, Junjun1; Wang, Jianping1; Xue, Yongbo1; Zhang, Yonghui1 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2017-03-17 |
| 卷号 | 82期号:6页码:3125-3131 |
| 英文摘要 | Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicydo[3.2.2]nonane-2,1'-cyclohexane] carbocydic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 mu g/mL. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | BINDING PROTEIN 2A ; BETA-LACTAM ANTIBIOTICS ; CELL-WALL ; MRSA ; COMBINATIONS ; INHIBITION ; PBP2A |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000397077500031 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51007]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhengxi,Sun, Weiguang,Li, Qin,et al. Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(6):3125-3131. |
| APA | Hu, Zhengxi.,Sun, Weiguang.,Li, Qin.,Li, Xiao-Nian.,Zhu, Hucheng.,...&Zhang, Yonghui.(2017).Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23.JOURNAL OF ORGANIC CHEMISTRY,82(6),3125-3131. |
| MLA | Hu, Zhengxi,et al."Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23".JOURNAL OF ORGANIC CHEMISTRY 82.6(2017):3125-3131. |
入库方式： OAI收割
来源：昆明植物研究所
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