Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase
文献类型：期刊论文
| 作者 | Hu, Rongkuan1,2,4,6; Yan, Huan3; Fei, Xiaoyan6; Liu, Haiyang3 ; Wu, Jiarui1,2,4,5
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-04-10 |
| 卷号 | 7页码:778 |
| 英文摘要 | AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2C12 myotubes by stimulating glucose transporter-4 (GLUT-4) membraned translocation. Treatment of primary mouse hepatocytes with shizukaol F decreased the expression of phosphoenolpyruvate carboxykinase 2 (PEPCK), glucose-6-phosphatase (G6Pase) and suppressed hepatic gluconeogenesis. Meanwhile, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice. Further studies indicated that shizukaol F modulates glucose metabolism mainly by AMPKa phosphorylation activity. In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits respiratory complex I, which may result in AMPK activation. Our results highlight the potential value of shizukaol F as a possible treatment of metabolic syndrome. |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | SKELETAL-MUSCLE ; METFORMIN ; ROSIGLITAZONE ; INCREASE ; AICAR ; GLUCONEOGENESIS ; ADIPOCYTES ; INHIBITION ; EXPRESSION ; OXIDATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000399071500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51062]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA |
| 推荐引用方式 GB/T 7714 | Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,et al. Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase[J]. SCIENTIFIC REPORTS,2017,7:778. |
| APA | Hu, Rongkuan,Yan, Huan,Fei, Xiaoyan,Liu, Haiyang,&Wu, Jiarui.(2017).Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase.SCIENTIFIC REPORTS,7,778. |
| MLA | Hu, Rongkuan,et al."Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase".SCIENTIFIC REPORTS 7(2017):778. |
入库方式： OAI收割
来源：昆明植物研究所
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