A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy
文献类型：期刊论文
| 作者 | Mou, Juan; Lin, Tianquan; Huang, Fuqiang; Shi, Jianlin; Chen, Hangrong |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:6页码:1531-1542 |
| 关键词 | green titania NIR absorption mitochondria photodynamic therapy photothermal therapy |
| 英文摘要 | A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm(-2)) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | VISIBLE-LIGHT PHOTOCATALYSIS ; PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; HYDROGEN-PRODUCTION ; TIO2 NANOPARTICLES ; BLACK TIO2 ; DIOXIDE ; PHOTOSENSITIZER ; HYPERTHERMIA ; OXIDATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000398783200011 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23767]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mou, Juan,Lin, Tianquan,Huang, Fuqiang,et al. A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy[J]. THERANOSTICS,2017,7(6):1531-1542. |
| APA | Mou, Juan,Lin, Tianquan,Huang, Fuqiang,Shi, Jianlin,&Chen, Hangrong.(2017).A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy.THERANOSTICS,7(6),1531-1542. |
| MLA | Mou, Juan,et al."A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy".THERANOSTICS 7.6(2017):1531-1542. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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