Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy
文献类型：期刊论文
| 作者 | Zhang, Chen1; Ni, Dalong1; Liu, Yanyan1; Yao, Heliang1; Bu, Wenbo1,2; Shi, Jianlin1 |
| 刊名 | NATURE NANOTECHNOLOGY
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 12期号:4页码:378-386 |
| 英文摘要 | A material that rapidly absorbs molecular oxygen (known as an oxygen scavenger or deoxygenation agent (DOA)) has various industrial applications, such as in food preservation, anticorrosion of metal and coal deoxidation. Given that oxygen is vital to cancer growth, to starve tumours through the consumption of intratumoral oxygen is a potentially useful strategy in fighting cancer. Here we show that an injectable polymer-modified magnesium silicide (Mg2Si) nanoparticle can act as a DOA by scavenging oxygen in tumours and form by-products that block tumour capillaries from being reoxygenated. The nanoparticles are prepared by a self-propagating high-temperature synthesis strategy. In the acidic tumour microenvironment, the Mg2Si releases silane, which efficiently reacts with both tissue-dissolved and haemoglobin-bound oxygen to form silicon oxide (SiO2) aggregates. This in situ formation of SiO2 blocks the tumour blood capillaries and prevents tumours from receiving new supplies of oxygen and nutrients. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | STIMULI-RESPONSIVE NANOCARRIERS ; INDUCED CELL-DEATH ; GOLD NANOPARTICLES ; SOLID TUMORS ; OXYGEN ; HYPOXIA ; ANGIOGENESIS ; COMBUSTION ; COMPOUND ; DELIVERY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000398767500019 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/23787]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chen,Ni, Dalong,Liu, Yanyan,et al. Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy[J]. NATURE NANOTECHNOLOGY,2017,12(4):378-386. |
| APA | Zhang, Chen,Ni, Dalong,Liu, Yanyan,Yao, Heliang,Bu, Wenbo,&Shi, Jianlin.(2017).Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.NATURE NANOTECHNOLOGY,12(4),378-386. |
| MLA | Zhang, Chen,et al."Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy".NATURE NANOTECHNOLOGY 12.4(2017):378-386. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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