中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications

文献类型:期刊论文

作者Wang JM(王佳敏)1; Shao, Xiangmin2; Wang, Jianhong1; Shao SJ(邵士俊)3,4,5
刊名Chemistry Letters
出版日期2017
卷号46期号:4页码:442-445
ISSN号0366-7022
关键词Fluorescence probe Bioimaging Thiol-containing molecule
通讯作者Wang, Jianhong ; 邵士俊
英文摘要

An NBD-based fluorescent probe (probe 1) for the detection of Hcy over Cys and GSH based on nucleophilic substitution and Smiles rearrangement reaction was designed and synthesized by the reaction of 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) with 1,4-dihydroxybenzene. The probe displayed many desired properties such as high specificity, appreciable solubility, and desirable response time. In addition, probe 1 has low cytotoxicity and detection of intracellular Hcy can be achieved by cell fluorescence imaging.

学科主题分析化学与药物化学
资助信息the National Natural Science Foundation of China (Nos. 21275150;21272056;21572239)
收录类别SCI
语种英语
WOS记录号WOS:000396814900007
源URL[http://210.77.64.217/handle/362003/21732]  
专题兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
作者单位1.Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Peoples R China
2.Zhengzhou Univ Ind Technol, Sch Pharm, Zhengzhou 451100, Peoples R China
3.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem NW Plant Resources, Lanzhou 730000, Peoples R China
4.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
5.Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Wang JM,Shao, Xiangmin,Wang, Jianhong,et al. An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications[J]. Chemistry Letters,2017,46(4):442-445.
APA Wang JM,Shao, Xiangmin,Wang, Jianhong,&Shao SJ.(2017).An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications.Chemistry Letters,46(4),442-445.
MLA Wang JM,et al."An NBD-based Fluorescent Turn-on Probe for the Detection of Homocysteine over Cysteine and Its Imaging Applications".Chemistry Letters 46.4(2017):442-445.

入库方式: OAI收割

来源:兰州化学物理研究所

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