Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles
文献类型：期刊论文
| 作者 | Yan, Y (Yan, Yue); Fu, J (Fu, Jie); Wang, TF (Wang, Tianfu) ; Lu, XY (Lu, Xiuyang)
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| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2017 |
| 卷号 | 51期号:3页码:471-478 |
| 关键词 | Drug delivery Silyl ether Click chemistry Mesoporous silica nanoparticles |
| 英文摘要 | As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this pro drug to mesoporous silica nanoparticles. Here, by altering the steric bulk of the substituent on the silicon atom, the release rate of a model drug, camptothecin, was controlled. The synthesized drug delivery system was investigated by analytical methods to confirm the functionalization and conjugation of the mesoporous silica nanoparticles. Herein, trimethyl silyl ether and triethyl silyl ether were selected to regulate the release rate. Under normal plasma conditions (pH 7.4), both types of camptothecin-loaded mesoporous silica nanoparticles (i.e., MSN-Me-CPT and MSN-Et-CPT) did not release the model drug. However, under in vitro acidic conditions (pH 4.0), based on a comparison of the release rates, camptothecin was released from MSN-Me-CPT more rapidly than from MSN-Et-CPT. To determine the biocompatibility of the modified mesoporous silica nanoparticles and the in vivo camptothecin uptake behavior, MIT assays with cancer cells and confocal microscopy observations were conducted, with positive results. These functionalized nanoparticles could be useful in clinical treatments requiring controlled drug release. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000398014000037 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/4779]  |
| 专题 | 新疆理化技术研究所_环境科学与技术研究室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | 1.Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn Minist Educ, Hangzhou 310027, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Y ,Fu, J ,Wang, TF ,et al. Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles[J]. ACTA BIOMATERIALIA,2017,51(3):471-478. |
| APA | Yan, Y ,Fu, J ,Wang, TF ,&Lu, XY .(2017).Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.ACTA BIOMATERIALIA,51(3),471-478. |
| MLA | Yan, Y ,et al."Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles".ACTA BIOMATERIALIA 51.3(2017):471-478. |
入库方式： OAI收割
来源：新疆理化技术研究所
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