The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli
文献类型：期刊论文
| 作者 | Ran, Rensen1,2; Zeng, Huan3; Zhao, Dong3; Liu, Ruiyuan1,2; Xu, Xia1 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 22期号:3 |
| 关键词 | microcin C7 heptapeptide cell growth membrane integrity |
| ISSN号 | 1420-3049 |
| 英文摘要 | Microcin C7 (McC), widely distributed in enterobacteria, is a promising antibiotic against antibiotic resistance. Previous studies have demonstrated that the heptapeptide of McC is only responsible for recognizing the inner membrane transporter YejABEF to deliver McC into microbial cells, but lacks the capacity for inhibiting microbial cell growth. In this study, the effect of the heptapeptide (MR) and two analogues, N-formylated heptapeptide (f-MR) and N-aceylated heptapeptide (a-MR), on microbial cell growth were examined. It is surprising to find that MR not only inhibits the activity of intracellular -galactosidase, respiratory chain dehydrogenases, and 6-phosphogluconate dehydrogenases (6PGDH), but it is also able to inhibit Escherichia coli growth, and eventually leads to cell death at the lethal concentration of 5.34 mM within 10 min. The modification of MR results in a slight increase in the lethal concentration. Cell membrane integrity at the lethal concentration confirms that MR undergoes the inhibition effect, but not by destroying the cell membrane integrity. The novel property of MR provides a new insight into the Trojan horse strategy of McC and opens a new route for antibiotics design. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ANTIMICROBIAL PEPTIDE ; OUTER-MEMBRANE ; 6-PHOSPHOGLUCONATE DEHYDROGENASE ; INHIBITOR ; ANTIBIOTICS ; PERMEABILITY ; RESISTANCE ; MECHANISM ; ANOPLIN ; ENTEROBACTERIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000398743500093 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/22151]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ran, Rensen,Zeng, Huan,Zhao, Dong,et al. The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli[J]. MOLECULES,2017,22(3). |
| APA | Ran, Rensen,Zeng, Huan,Zhao, Dong,Liu, Ruiyuan,&Xu, Xia.(2017).The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli.MOLECULES,22(3). |
| MLA | Ran, Rensen,et al."The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli".MOLECULES 22.3(2017). |
入库方式： OAI收割
来源：过程工程研究所
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