Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells
文献类型：期刊论文
| 作者 | Li H(李红) ; Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉); Long M
|
| 刊名 | Science China-Life Sciences
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:9页码:1085-1091 |
| 通讯作者邮箱 | mlong@imech.ac.cn |
| 关键词 | Substrate Orientation Osteoblasts Cell Shape Cell Cycle Cytoskeleton Random Positioning Machine Microgravity Osteoblasts Space Spaceflight Adhesion Gravity Nuclei Flight |
| ISSN号 | 1674-7305 |
| 通讯作者 | Long M |
| 中文摘要 | Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity. |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | RANDOM POSITIONING MACHINE ; MICROGRAVITY ; OSTEOBLASTS ; SPACE ; SPACEFLIGHT ; ADHESION ; GRAVITY ; NUCLEI ; FLIGHT |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences [KJCX2-YW-L08]; National Natural Science Foundation of China [30730032, 30730093]; National Key Basic Research Foundation of China [2006CB910303]; National High Technology Research and Development Program of China [2007AA02Z306] |
| 原文出处 | http://www.scichina.com:8082/sciCe/EN/abstract/abstract500479.shtml# |
| 语种 | 英语 |
| WOS记录号 | WOS:000282479500005 |
| 公开日期 | 2011-03-01 ; 2011-03-30 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/43627]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 通讯作者 | Long M |
| 推荐引用方式 GB/T 7714 | Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010,53(9):1085-1091. |
| APA | Li H.,陈娟.,章燕.,孙树津.,陶祖莱.,...&Long M.(2010).Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.Science China-Life Sciences,53(9),1085-1091. |
| MLA | Li H,et al."Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells".Science China-Life Sciences 53.9(2010):1085-1091. |
入库方式： OAI收割
来源：力学研究所
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