Dynamics of morphological changes for mitochondrial fission and fusion
文献类型：期刊论文
| 作者 | Wang SQ(王世骐); Fu ZL(付长亮) ; Zhang Y(章燕); Chen Q; Long M(龙勉); Long M
|
| 刊名 | Science China-Physics Mechanics & Astronomy
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:4页码:680-689 |
| 通讯作者邮箱 | mlong@imech.ac.cn |
| ISSN号 | 1674-7348 |
| 通讯作者 | Long M |
| 合作状况 | 国内 |
| 中文摘要 | Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume. |
| 类目[WOS] | Physics, Multidisciplinary |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | LIVING CELLS ; RETICULUM ; TRANSPORT |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30730032, 10332060]; National Key Basic Research Foundation of China [2006CB910303]; National High Technology Research and Development Program of China [2007AA02Z306]; Chinese Academy of Sciences [KJCX2-YW-L08] |
| 原文出处 | http://www.springerlink.com/content/x4183qv224878693/ |
| 语种 | 英语 |
| WOS记录号 | WOS:000276776100012 |
| 公开日期 | 2011-03-01 ; 2011-03-30 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/43665]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 通讯作者 | Long M |
| 推荐引用方式 GB/T 7714 | Wang SQ,Fu ZL,Zhang Y,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. Science China-Physics Mechanics & Astronomy,2010,53(4):680-689. |
| APA | 王世骐,付长亮,章燕,Chen Q,龙勉,&Long M.(2010).Dynamics of morphological changes for mitochondrial fission and fusion.Science China-Physics Mechanics & Astronomy,53(4),680-689. |
| MLA | 王世骐,et al."Dynamics of morphological changes for mitochondrial fission and fusion".Science China-Physics Mechanics & Astronomy 53.4(2010):680-689. |
入库方式： OAI收割
来源：力学研究所
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