Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients
文献类型：期刊论文
| 作者 | Xu, GW; Yao, QH; Weng, QF; Su, BL; Zhang, X; Xiong, JH |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2004-09-21 |
| 卷号 | 36期号:1页码:101-104 |
| 关键词 | oxidative DNA damage 8-hydroxydeoxyguanosine diabetic nephropathy |
| 产权排序 | 1;1 |
| 英文摘要 | increased oxidative stress induced by hyperglycemia may contribute to the pathogenesis of diabetic complications. urinary 8-hydroxydeoxyguanosine (8-ohdg) has been reported to serve as a sensitive biomarker of oxidative dna damage and also of oxidative stress. this article studied oxidative dna damage in patients with diabetic nephropathy and in healthy control subjects by urinary 8-ohdg evaluations. contents of 8-ohdg in urine were analyzed by capillary electrophoresis with end-column amperometric detection (ce-ad) after a single-step solid-phase extraction (spe). levels of urinary 8-ohdg in diabetic nephropathy patients with macroalbuminuria was significant higher than in control subjects (5.72 +/- 6.89 mumol/mol creatinine versus 2.33 +/- 2.83 mumol/mol creatinine, p = 0.018). a significant difference of 24 h urinary 8-ohdg excretions exists between the patients with macroalbuminuria and the patients with nonnoalbuminuria (19.2 +/- 16.8 mug/24 h versus 8.1 +/- 1.7 mug/24 h, p = 0.015). there was a positive correlation between urinary excretion of 8-ohdg and glycosylated hemoglobin (hba(1)c) (r = 0.287, p = 0.022). a weak correlation exists between the levels of 8-ohdg and triglyceride (r = 0.230, p = 0.074). however, the urinary 8-ohdg contents are not correlated with blood pressure and total cholesterol. the increased excretion of urinary 8-ohdg is seen as indicating an increased systemic level of oxidative dna damage in diabetic nephropathy patients. (c) 2004 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | column amperometric detection ; dynamic ph junction ; capillary-electrophoresis ; electrochemical detection ; stress ; complications ; mellitus ; 8-hydroxy-2'-deoxyguanosine ; hyperglycemia ; excretion |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000224328000013 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/81605]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&D Ctr, Dalian 116011, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, GW,Yao, QH,Weng, QF,et al. Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients[J]. journal of pharmaceutical and biomedical analysis,2004,36(1):101-104. |
| APA | Xu, GW,Yao, QH,Weng, QF,Su, BL,Zhang, X,&Xiong, JH.(2004).Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients.journal of pharmaceutical and biomedical analysis,36(1),101-104. |
| MLA | Xu, GW,et al."Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients".journal of pharmaceutical and biomedical analysis 36.1(2004):101-104. |
入库方式： OAI收割
来源：大连化学物理研究所
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