DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices
文献类型：期刊论文
| 作者 | Oin, JH; Fung, YS; Lin, BC |
| 刊名 | expert review of molecular diagnostics
 |
| 出版日期 | 2003-05-01 |
| 卷号 | 3期号:3页码:387-394 |
| 关键词 | capillary electrophoresis DNA diagnosis microchip microfluidic mutation SNP STRs |
| 产权排序 | 1;1 |
| 英文摘要 | dna diagnosis is experiencing an impressive progression towards the development of novel technology to identity various clinically relevant categories of genetic changes and to meet the exponential growth of genomics. the introduction of capillary electrophoresis has dramatically accelerated the completion of the first draft of the human dna sequence in the human genome project, and thus, has become the method of choice for analysis of various genetic variants. the recent development of microfabricated electrophoretic devices has led to the possibility of integrating multiple sample handling with the actual measurement steps required for automation of molecular diagnostics. this review highlights the most recent progress in capillary electrophoresis and electrophoretic microdevices for dna-based diagnostics, including the important areas of genotyping for point mutation, single nucleotide polymorphisms, short tandem repeats and organism identification. the application of these techniques for infectious and genetic disease diagnosis, as well as forensic identification purpose, are covered. the promising development and the challenges for techinical problems are also discussed. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | pathology |
| 研究领域[WOS] | pathology |
| 关键词[WOS] | linear polyacrylamide solutions ; polymerase-chain-reaction ; strand conformation polymorphism ; total analysis systems ; short tandem repeats ; array electrophoresis ; microchip electrophoresis ; high-throughput ; 1000 bases ; heteroduplex analysis |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000188437800010 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/83393]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Oin, JH,Fung, YS,Lin, BC. DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices[J]. expert review of molecular diagnostics,2003,3(3):387-394. |
| APA | Oin, JH,Fung, YS,&Lin, BC.(2003).DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices.expert review of molecular diagnostics,3(3),387-394. |
| MLA | Oin, JH,et al."DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices".expert review of molecular diagnostics 3.3(2003):387-394. |
入库方式： OAI收割
来源：大连化学物理研究所
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