Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers
文献类型：期刊论文
| 作者 | Huang, XD; Zou, HF; Chen, XM; Luo, QZ; Kong, L |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2003-01-17 |
| 卷号 | 984期号:2页码:273-282 |
| 关键词 | molecular imprinting stationary phases monolithic LC enantiomer separation diastereomer separation |
| 产权排序 | 1;1 |
| 英文摘要 | the method for preparation of molecularly imprinted monolithic stationary phase has been improved to achieve liquid chromatographic separation of enantiomers and diastereomers. by adopting low polar porogenic solvents of toluene and dodecanol and optimal polymerization conditions, the molecularly imprinted monolithic stationary phases with good flow-through properties and high resolution were prepared. enantiomers of amino acid derivatives and diastereomers of cinchona alkaloids were completely resolved using the monolithic stationary phases. the influence of porogenic composition, monomer-template ratio and polymerization conditions on the chromatographic performance was investigated. some chromatographic conditions such as the composition of the mobile phase and the temperature were characterized. scanning electron microscopy showed that the molecularly imprinted monolithic stationary phase has a large through-pore structure to allow the mobile phase to flow through the column at very low backpressure. accelerated separations of enantiomers and diastereomers were therefore achieved at elevated flow rates. finally, the chiral recognition performance of the prepared stationary phase in aqueous media was investigated. hydrophobic interaction, and ionic and/or hydrogen bonding interactions were proposed to be responsible for the recognition mechanism. (c) 2002 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | capillary electrochromatography ; suspension polymerization ; chiral recognition ; solute retention ; affinity media ; polymers ; selectivity ; perfluorocarbon ; template ; beads |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000180309800013 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/83449]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, XD,Zou, HF,Chen, XM,et al. Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers[J]. journal of chromatography a,2003,984(2):273-282. |
| APA | Huang, XD,Zou, HF,Chen, XM,Luo, QZ,&Kong, L.(2003).Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers.journal of chromatography a,984(2),273-282. |
| MLA | Huang, XD,et al."Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers".journal of chromatography a 984.2(2003):273-282. |
入库方式： OAI收割
来源：大连化学物理研究所
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