Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent
文献类型：期刊论文
| 作者 | Koppenhoefer, B; Jakob, A; Zhu, XF; Lin, BC |
| 刊名 | hrc-journal of high resolution chromatography
 |
| 出版日期 | 2000-06-01 |
| 卷号 | 23期号:6页码:413-429 |
| 关键词 | capillary electrophoresis enantiomer separation chiral drugs TM-gamma-cyclodextrin |
| 英文摘要 | high-throughput screening is a promising new approach in analytical chemistry. within the framework of an extended screening program (the german-chinese drug screening program), the enantioseparation of 86 drugs was investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (csa) octakis-(2,3,6-tri-o-methyl)-gamma-cyclodextrin (tm-gamma-cd). by this means, 15 drugs could be separated into enantiomeric pairs. approximate measures for the degree of interaction (migration retardation factor, r-m) and for the degree of enantiomer recognition (migration separation factors, alpha(m)) revealed intriguing patterns that were compared with those found for native gamma-cyclodextrin (gamma-cd). although there is a distinct influence of the analyte structure on the electrophoretic data, interpretation remains difficult. most remarkably, permethylation of gamma-cd leads neither to a higher affinity nor to better chiral recognition, in contrast to the findings with alpha-cd. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | hydroxypropyl-beta-cyclodextrin ; zone electrophoresis ; basic drugs ; electrokinetic chromatography ; alpha-cyclodextrin ; amino-alcohols ; resolution ; parameters ; additives ; phase |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000088042800002 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/84003]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen, Inst Organ Chem, D-72074 Tubingen, Germany 2.Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Koppenhoefer, B,Jakob, A,Zhu, XF,et al. Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent[J]. hrc-journal of high resolution chromatography,2000,23(6):413-429. |
| APA | Koppenhoefer, B,Jakob, A,Zhu, XF,&Lin, BC.(2000).Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent.hrc-journal of high resolution chromatography,23(6),413-429. |
| MLA | Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent".hrc-journal of high resolution chromatography 23.6(2000):413-429. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。