Transient state of chiral recognition in a binary mixture of cyclodextrins in capillary electrophoresis
文献类型：期刊论文
| 作者 | Zhu, XF; Ding, YS; Lin, BC; Jakob, A; Koppenhoefer, B |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2000-08-04 |
| 卷号 | 888期号:1-2页码:241-250 |
| 关键词 | enantiomer separation chiral selectors transient state buffer composition cyclodextrins aminoglutethimide |
| 英文摘要 | the transient state (as the defined point where no enantioseparation is obtained in a dual chiral selector system) of chiral recognition of aminoglutethimide in a binary mixture of neutral cyclodextrins (cds) was studied by capillary electrophoresis (ce). the following three dual selector systems were used: alpha-cyclodextrin (alpha-cd) and beta-cyclodextrin (beta-cd); alpha-cd and heptakis(di-o-methyl-beta-cyclodextrin) (dm-beta-cd); alpha-cd and heptakis(tri-o-methyl-beta-cyclodextrin) (tm-beta-cd). the s-(-) enantiomer of the analyte was more strongly retained in the presence of either alpha-cd or tm-beta-cd at ph 2.5, 100 mm phosphate buffer, while the r-(+) enantiomer was more strongly retained in the presence of either p-cd or dm-p-cd. in the more simple case, the elution order is invariably kept if the enantiomers have the same elution order in either one of the two hosts of the binary mixture. in contrast, the elution order may be switched by varying the concentration ratio of two hosts that produce opposite elution order for this particular analyte. in such a dual selector system, the enantioselectivity will disappear at the transient state at a certain ratio of host,:host, moreover, the migration times of the two enantiomers with host, alone (diluted in buffer) is approximately equal to the migration times at the corresponding concentration of host, alone (diluted in buffer), where the ratio of concentrations of host,:host, is the same as in the binary mixture at the transient state. as found by nuclear magnetic resonance experiments, the analyte is forming a 1:1 complex with either one of the cds applied. from this finding, a theoretical model based on the mobility difference of the two enantiomers was derived that was used to simulate the transient state. (c) 2000 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | liquid-chromatographic separation ; drugs ; aminoglutethimide ; agent ; enantiomers ; metabolite |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000088414100024 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/84021]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Zhu, XF,Ding, YS,Lin, BC,et al. Transient state of chiral recognition in a binary mixture of cyclodextrins in capillary electrophoresis[J]. journal of chromatography a,2000,888(1-2):241-250. |
| APA | Zhu, XF,Ding, YS,Lin, BC,Jakob, A,&Koppenhoefer, B.(2000).Transient state of chiral recognition in a binary mixture of cyclodextrins in capillary electrophoresis.journal of chromatography a,888(1-2),241-250. |
| MLA | Zhu, XF,et al."Transient state of chiral recognition in a binary mixture of cyclodextrins in capillary electrophoresis".journal of chromatography a 888.1-2(2000):241-250. |
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来源：大连化学物理研究所
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