Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins
文献类型：期刊论文
| 作者 | Koppenhoefer, B; Zhu, XF; Jakob, A; Wuerthner, S; Lin, BC |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2000-04-14 |
| 卷号 | 875期号:1-2页码:135-161 |
| 关键词 | reviews enantiomer separation cyclodextrins drugs |
| 英文摘要 | this is a selected review, highlighting our results obtained in an extended screening program ("the german-chinese drug screening program"), with a focus on a set of original data obtained with heptakis(2,3,6-tri-o-methyl)-beta-cyclodextrin(tm-beta-cd) as the chiral solvating agent (csa). the enantioseparation of 86 drugs by capillary zone electrophoresis in the presence of this csa was successful for 47 drugs. the migration separation factors (alpha(m)) and the migration retardation factors (r-m) were compared with those found for native beta-cyclodextrin (beta-cd). the patterns thus obtained were also compared with those observed for hexakis(2,3,6-tri-o-methyl)-alpha-cd (tm-alpha-cd) and octakis(2,3,6-tri-o-methyl)-gamma-cd (tm-gamma-cd), respectively. from the statistical data, it can be concluded that there is a remarkable influence of the analyte structure on the electrophoretic data. a substructure 4h was found in the analyte structure that has a significant influence on the analytes' behaviour. thus, analytes bearing the substructure 4h do not only have a strong affinity to the cds but also a high rate of success of chiral separation in all systems reviewed. in light of this, the different ring sizes of native cyclodextrins (alpha-, beta- and gamma-cd) readily explain their behaviour towards a limited test set of chiral drugs. sterical considerations point to the significance of side-on-binding versus inclusion in the cavity of the host. in addition to the findings from the screening program, numerous references to the literature are given. (c) 2000 elsevier science b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | chiral solvating agent ; pharmacologically active substances ; pseudo-stationary phases ; zone electrophoresis ; beta-cyclodextrin ; electrokinetic chromatography ; basic drugs ; alpha-cyclodextrin ; gamma-cyclodextrin ; theoretical aspects |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000086738800007 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/84023]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany 2.Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Koppenhoefer, B,Zhu, XF,Jakob, A,et al. Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins[J]. journal of chromatography a,2000,875(1-2):135-161. |
| APA | Koppenhoefer, B,Zhu, XF,Jakob, A,Wuerthner, S,&Lin, BC.(2000).Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins.journal of chromatography a,875(1-2),135-161. |
| MLA | Koppenhoefer, B,et al."Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins".journal of chromatography a 875.1-2(2000):135-161. |
入库方式： OAI收割
来源：大连化学物理研究所
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