Air oxidation and rearrangement reactions of methyl(pyro)pheophorbide-a in the presence of lithium hydroxide
文献类型：期刊论文
| 作者 | Li Jia-Zhu2,3; Liu Wan-Hui3; Li Fu-Guo2; Wang Jin-Jun1,2; Suo You-Rui1; Liu Yong-Jun1 |
| 刊名 | chinese journal of organic chemistry
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 27期号:12页码:1594-1599 |
| 关键词 | chlorophyll-a methyl(pyro)pheophorbide-a air oxidation rearrangement reaction photodynamic therapy |
| 英文摘要 | in the presence of lithium hydroxide, air oxidation and rearrangement reactions of methyl pheophorbide-a (1a) followed by acidification with hydrochloric acid and methylation with diazomethane to give a mixture including purpurin-7 trimethyl ester (2), purpurin-18 methyl ester (3), chlorine-p(6) trimethyl ester (4), geoporphyrin derivatives (5) and 3-epoxyvinyl-3-devinylpurpurin-18 ester (6) were performed. methyl pyropheophorbide-a (1b) was oxidized in the same reaction as chlorin la followed by chromatography isolation to obtain methyl 13 2 -oxopyropheophorbide-a (7), 15-formylpurpurin-5 dimehyl ester (8), purpurin-18 methyl ester (3) and 3-epoxyvinyl-3-devinylpurpurin-18 ester (6), respectively. the structures of new chlorophyll derivatives 5, 6 and 8 were characterized by uv, ir, h-1 nmr spectra and elemental analysis. the possible mechanisms for the air oxidation and rearrangement reaction were tentatively proposed. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | chlorophyll-a ; photodynamic therapy ; pyropheophorbide-a ; visible spectra ; derivatives ; photosensitizers ; antioxidants ; purpurin-18 ; chlorin |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251996300024 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6866]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810001, Peoples R China 2.Yantai Univ, Sci & Engn Coll Chem & Biol, Yantai 264005, Peoples R China 3.Yantai Univ, Coll Pharm, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Jia-Zhu,Liu Wan-Hui,Li Fu-Guo,et al. Air oxidation and rearrangement reactions of methyl(pyro)pheophorbide-a in the presence of lithium hydroxide[J]. chinese journal of organic chemistry,2007,27(12):1594-1599. |
| APA | Li Jia-Zhu,Liu Wan-Hui,Li Fu-Guo,Wang Jin-Jun,Suo You-Rui,&Liu Yong-Jun.(2007).Air oxidation and rearrangement reactions of methyl(pyro)pheophorbide-a in the presence of lithium hydroxide.chinese journal of organic chemistry,27(12),1594-1599. |
| MLA | Li Jia-Zhu,et al."Air oxidation and rearrangement reactions of methyl(pyro)pheophorbide-a in the presence of lithium hydroxide".chinese journal of organic chemistry 27.12(2007):1594-1599. |
入库方式： OAI收割
来源：西北高原生物研究所
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