Efficient One-Pot Synthesis of Highly Substituted Thiophene Library from 1,3-Dicarbonyl Compounds
文献类型：期刊论文
| 作者 | Wang Y ; Huang J ; Chai YY ; Liu Q ; Liang YJ ; Dong DW* |
| 刊名 | journal of combinatorial chemistry
 |
| 出版日期 | 2008 |
| 卷号 | 10期号:4页码:511-516 |
| 关键词 | OXO KETENE DITHIOACETALS TETRASUBSTITUTED THIOPHENES CONVENIENT SYNTHESIS PRACTICAL SYNTHESIS ORGANIC-SYNTHESIS CARBON-DISULFIDE GEWALD REACTION SOLID-SUPPORT ANNULATION FACILE |
| ISSN号 | 1520-4766 |
| 通讯作者 | dewen dong |
| 中文摘要 | a faccile and efficient one-pot synthesis of highly substituted thiophenes has been developed and employed for the preparation of a small focused library. treatment of 1,3-dicarbonyl compounds 1 with cs2 in the presence of k2co3 in dmf at room temperature, followed by stepwise addition of alkyl bromides 2 and methylene active bromides 3, provided via intramolecular cyclization 2,3,4,5-tetrasubstituted thiophenes 4 in yields of 77-94%. this protocol, combining construction and modification of the thiophene ring, increases the structural diversity of final products from readily available materials. a mechanism for the one-pot synthesis of thiophenes of type 4 has been proposed. a small focused library of thiophenes is prepared using the sequential addition of reagents to achieve unique substitution in the 2 and 5 position of the thiophene ring |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257664800006 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/9701]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang Y,Huang J,Chai YY,et al. Efficient One-Pot Synthesis of Highly Substituted Thiophene Library from 1,3-Dicarbonyl Compounds[J]. journal of combinatorial chemistry ,2008,10(4):511-516. |
| APA | Wang Y,Huang J,Chai YY,Liu Q,Liang YJ,&Dong DW*.(2008).Efficient One-Pot Synthesis of Highly Substituted Thiophene Library from 1,3-Dicarbonyl Compounds.journal of combinatorial chemistry ,10(4),511-516. |
| MLA | Wang Y,et al."Efficient One-Pot Synthesis of Highly Substituted Thiophene Library from 1,3-Dicarbonyl Compounds".journal of combinatorial chemistry 10.4(2008):511-516. |
入库方式： OAI收割
来源：长春应用化学研究所
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