Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment
文献类型：期刊论文
| 作者 | Wei JC(韦佳辰); Song F(宋凡)
|
| 刊名 | INTERNATIONAL JOURNAL OF MODERN PHYSICS B
 |
| 出版日期 | 2017-01-30 |
| 卷号 | 31期号:3 |
| 关键词 | Globular protein association equilibria short-range attraction macromolecular crowding |
| ISSN号 | 0217-9792 |
| 中文摘要 | Based on a very simple coarse-grained colloidal model here we implement an effective hard-sphere theory and numerical simulation to capture the general features of the association equilibria for globular proteins in crowded environment. We measure the activity coefficient i.e. the deviation from ideal behavior of protein solution and the crowding factor i.e. the contribution of crowders to the association equilibria for proteins in macromolecular crowding. The results show that the association balance in macro molecular crowding depends sensitively on the magnitude of protein-crowder attraction and the relative size of reactant to crowding agent. Since our coarse-grained model is irrelevant to the microscopic details of the molecules it can be applied to the control of the association equilibria of many globular proteins such as bovine serum albumin crystallin and lysozyme. |
| 类目[WOS] | Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | BOVINE SERUM-ALBUMIN ; LIGHT-SCATTERING ; MODEL ; DEPENDENCE ; REPULSION ; SPHERES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000395314300007 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/60591]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wei JC,Song F. Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2017,31(3). |
| APA | 韦佳辰,&宋凡.(2017).Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,31(3). |
| MLA | 韦佳辰,et al."Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 31.3(2017). |
入库方式： OAI收割
来源：力学研究所
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