Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity
文献类型：期刊论文
| 作者 | Ding KL(丁奎岭) ; Du HF(杜海峰) ; Yuan Y(袁宇) ; Long J(龙江) |
| 刊名 | Chem.-Eur. J.
 |
| 出版日期 | 2004 |
| 卷号 | 10期号:12页码:2872-2884 |
| ISSN号 | 0947-6539 |
| 其他题名 | 组合不对称催化：合理设计与偶然机遇 |
| 通讯作者 | 丁奎岭 |
| 英文摘要 | An efficient asymmetric catalyst relies on the successful combination of a large number of interrelated variables, including rational design, intuition, persistence, and good fortune-not all of which are necessarily well-understood; this renders such practice largely empirical. As a result, the possibility of using combinatorial chemistry methods in asymmetric catalysis research has been widely recognized to be highly desirable. In this account, we attempt to show the principle and application of combinatorial approach in the discovery of chiral catalysts for enantioselective reactions. The concept focuses on the strategy for the creation of a modular chiral catalyst library by two-component ligand modification of metal ions on the basis of molecular recognition and assembly. The self-assembled chiral catalyst with two different ligands indeed exhibited synergistic effects in terms of both enantioselectivity and activity in comparison with its corresponding homocombinations in many reactions. The examples described in this paper demonstrated the powerfulness of combinatorial approach for the discovery of novel chiral catalyst systems, particularly for the development of highly efficient, enantioselective, and practical catalysts for enantioselective reactions. We hope this concept will stimulate further work on the discovery of more highly efficient and enantioselective catalysts, as well as unexpected classes of catalysts or catalytic enantioselective reactions in the future with the help of a combinatorial chemistry approach. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/chem.200305707 |
| 语种 | 英语 |
| WOS记录号 | WOS:000222312800001 |
| 公开日期 | 2013-02-22 |
| 源URL | [http://202.127.28.38/handle/331003/17771]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ding KL,Du HF,Yuan Y,et al. Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity[J]. Chem.-Eur. J.,2004,10(12):2872-2884. |
| APA | 丁奎岭,杜海峰,袁宇,&龙江.(2004).Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity.Chem.-Eur. J.,10(12),2872-2884. |
| MLA | 丁奎岭,et al."Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity".Chem.-Eur. J. 10.12(2004):2872-2884. |
入库方式： OAI收割
来源：上海有机化学研究所
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